Duloxetine EP Impurity F Hydrochloride CAS 2748376-86-3
| CAS No. | 2748376-86-3 |
| Molecular Formula | C18H19NOS |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Duloxetine EP Impurity F Hydrochloride (CAS 2748376-86-3), a pharmacopoeial impurity reference standard (molecular formula C18H19NOSHCl, MW 333.87 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a steroid core, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution, Duloxetine EP Impurity F Hydrochloride is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 333.87 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H19NOS HCl |
| Molecular Weight | 333.87 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2002 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Duloxetine Standards
- Duloxetine EP Impurity E HCl (CAS 1033719-36-6)
- Duloxetine EP Impurity E (CAS 1033803-59-6)
- Duloxetine Impurity 55 (CAS 1045348-04-6)
- Duloxetine Impurity 9 (CAS 110-14-5)
- rac-Duloxetine EP Impurity F HCl (CAS 1104890-90-5)
- Duloxetine EP Impurity B (CAS 116539-55-0)
- Duloxetine Impurity (CAS 116539-57-2)
- Duloxetine (CAS 116539-59-4)
Recommended Standards
- Olmesartan Medoxomil EP Impurity B (CAS 849206-43-5)
- Ivabradine impurity 83 (CAS CATO-C4X-111983)
- Propranolol Impurity 30 (CAS 27827-19-6)
- 4-Cyano-1H-imidazole-5-carboxamide (CAS 5372-23-6)
- 4-Phenylquinazolin-2(1H)-one (CAS 23441-75-0)
- 5-Methoxy-7-methyl-2,3-dihydro-1h-indole-2,3-dione (CAS 343774-48-1)
- 5-Chloro-2-sulfanylbenzonitrile (CAS 38244-31-4)
- 4-Chloro-N-methylpyridine-3-sulfonamide (CAS 56397-15-0)
- (4Z)-4-{[(2-hydroxyphenyl)amino]methylidene}-1-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-one (CAS 320425-03-4)
- Neuropeptide EI (human, mouse, rat) (CAS 125934-45-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com