Sitagliptin Impurity 154 CAS 2749805-70-5
| CAS No. | 2749805-70-5 |
| Molecular Formula | C16H18F3N5O |
| Molecular Weight | 353.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Sitagliptin Impurity 154 (C16H18F3N5O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Sitagliptin Impurity 154 (CAS 2749805-70-5) is a certified pharmaceutical impurity reference standard with the molecular formula C16H18F3N5O and a molecular weight of 353.34 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Sitagliptin Impurity 154 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H18F3N5O |
| Molecular Weight | 353.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2002 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Sitagliptin Standards
- Sitagliptin Impurity 26 (CAS 1402569-71-4)
- Sitagliptin Impurity 39 (CAS CATO-C4X-1144139)
- Sitagliptin Impurity 83 (CAS 1574485-30-5)
- Sitagliptin Impurity 3 (CAS CATO-C4X-11443)
- Sitagliptin Impurity 150 (CAS 945261-47-2)
- Sitagliptin Impurity 124 (CAS CATO-C4X-1144124)
- Sitagliptin Impurity 18 (CAS 922178-94-7)
- Sitagliptin Impurity 28 (CAS 486460-00-8)
Recommended Standards
- N'-methyl-N'-(3-phenyl-6-(trifluoromethyl)-1,2,4-triazin-5-yl)pivalohydrazide (CAS 672951-04-1)
- ((2,4-Dioxo-2,3,4,5-tetrahydro-1h-benzo[b][1,4]diazepin-7-yl)sulfonyl)proline (CAS 1044637-60-6)
- N'-methyl-N'-(3-phenyl-6-(trifluoromethyl)-1,2,4-triazin-5-yl)pentanehydrazide (CAS 672951-07-4)
- 4-((4-(N-(5-methylisoxazol-3-yl)sulfamoyl)phenyl)amino)-4-oxobutanoic acid (CAS 133071-57-5)
- Sunitinib Impurity 24 (CAS 1467015-10-6)
- Avanafil Impurity 122 (CAS CATO-C4X-1118122)
- Relugolix Impurity 182 (CAS CATO-C4X-2429182)
- Diethyl 2-(((4-benzoyl-1-(2,4-dichlorobenzyl)-5-methyl-1H-pyrrol-3-yl)amino)methylene)malonate (CAS 339028-63-6)
- N-(2-Amino-5,6,7,8-tetrahydroquinazolin-6-yl)acetamide (CAS 285139-04-0)
- 2-(2-Chloro-3,6-difluorophenyl)acetic acid (CAS 261762-52-1)
- Ethyl 5-(trifluoromethyl)-1-[5-(trifluoromethyl)pyridin-2-yl]-1h-pyrazole-4-carboxylate (CAS 1172939-75-1)
- 4-(4-(Benzyloxy)-2-methylbenzoyl)-1-(2-(diethylamino)ethyl)-3-hydroxy-5-(pyridin-4-yl)-1H-pyrrol-2(5H)-one (CAS 488132-09-8)
- 2-Phenylfuro[3,2-c]quinoline (CAS 1449680-34-5)
- Semaglutide Impurity 187 (CAS CATO-C4X-2226187)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com