Sitagliptin Impurity 83 CAS 1574485-30-5
| CAS No. | 1574485-30-5 |
| Molecular Formula | C14H10F6N4O |
| Molecular Weight | 364.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Sitagliptin Impurity 83 (CAS 1574485-30-5, C14H10F6N4O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Sitagliptin Impurity 83 (C14H10F6N4O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 364.25 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Sitagliptin Impurity 83 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H10F6N4O |
| Molecular Weight | 364.25 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Sitagliptin Standards
- Sitagliptin Impurity 3 (CAS CATO-C4X-11443)
- Sitagliptin Impurity 39 (CAS CATO-C4X-1144139)
- Sitagliptin Impurity 150 (CAS 945261-47-2)
- Sitagliptin Impurity 154 (CAS 2749805-70-5)
- Sitagliptin Impurity 102 (CAS CATO-C4X-1144102)
- Sitagliptin Impurity 26 (CAS 1402569-71-4)
- Sitagliptin Impurity 68 (CAS CATO-C4X-114468)
- Sitagliptin Impurity 69 (CAS CATO-C4X-114469)
Recommended Standards
- N'-[(1Z)-(2,4-Dichlorophenyl)methylidene]-3-(1H-pyrrol-1-yl)thiophene-2-carbohydrazide (CAS 478063-24-0)
- 3-Bromo-2-methyl-1-tosyl-1H-indole (CAS 1060812-81-8)
- N-(3,5-dichlorophenyl)-4-methyl-2-(pyridin-2-yl)thiazole-5-carboxamide (CAS 400079-03-0)
- Methyl 2-((4-bromophenyl)sulfonamido)-3,3-dimethylbutanoate (CAS 1214641-26-5)
- Safinamide Impurity 68 (CAS CATO-C4X-159068)
- Olaparib Impurity N12 (CAS 763114-04-1)
- Bempedoic Acid Impurity 4 (CAS 143958-75-2)
- 9-bromofluorene (CAS 1940-57-4)
- 4-amino-N,3-dimethyl-1H-pyrazole-5-carboxamide (CAS 68375-44-0)
- (R)-2-(2,5-Dimethoxyphenyl)piperazine (CAS 1212929-05-9)
- (3R,5R)-piperidine-3,5-diol;hydrochloride (CAS 2719682-90-1)
- Tadalafil Impurity 90 (CAS 1978323-00-0)
- 4,5-Dihydro-2,4-benzoxazepin-3(1H)-one (CAS 39976-24-4)
- Neuropeptide GE (CAS 134748-04-2)
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