7-Bromo-4,6-dichloro-8-fluoro-2-(methylthio)quinazoline CAS 2757097-20-2
| CAS No. | 2757097-20-2 |
| Molecular Formula | C9H4BrCl2FN2S |
| Molecular Weight | 342.01 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
7-Bromo-4,6-dichloro-8-fluoro-2-(methylthio)quinazoline (CAS 2757097-20-2), molecular formula C9H4BrCl2FN2S and molecular weight 342.01 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 7-Bromo-4,6-dichloro-8-fluoro-2-(methylthio)quinazoline (C9H4BrCl2FN2S) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine/chlorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 7-Bromo-4,6-dichloro-8-fluoro-2-(methylthio)quinazoline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H4BrCl2FN2S |
| Molecular Weight | 342.01 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2002 |
| Halogen Content | F/Cl/Br-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Bromo Standards
- 7-Bromo-2,6-dichloro-8-fluoro-4-(methylthio)quinazoline (CAS 2857929-87-2)
- 7-Bromo-5-chloro-2-(4-chlorophenyl)-1H-benzo[d]imidazole (CAS 16429-30-4)
- 5-Bromo-7-chloro-2-(4-chlorophenyl)-1H-benzo[d]imidazole (CAS 16429-36-0)
- 1-Bromo-4-(4-(bromomethyl)phenoxy)benzene (CAS 1344045-86-8)
- 3-Bromo-5-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)phenylboronic acid (CAS 2377608-48-3)
- Bis(5-bromo-2-pyridinyl)methanone (CAS 656828-00-1)
- 5-Bromo-2-isopropoxypyridine-3-boronic acid pinacol ester (CAS 2121511-77-9)
- (S)-3-Bromo-5-iodo-2-(1-methoxyethyl)pyridine (CAS 2641451-76-3)
Recommended Standards
- Ketoconazole impurity 31 (CAS CATO-C4X-147231)
- Methyl 5-(2,2-dibromoacetyl)thiophene-2-carboxylate (CAS 656227-47-3)
- Ketoconazole Impurity 8 (Mixture of diastereomers) (CAS 68751-57-5)
- 1,2-Dibromo-4,5-diethoxy-3-fluorobenzene (CAS 474554-34-2)
- 3-(4,6-Dimethyl-2-oxoquinolin-1(2H)-yl)propanoic acid (CAS 370841-34-2)
- 6-(Di-Boc-amino)-2-bromopyridine, 97% (CAS 870703-61-0)
- 1,3,5-Benzenetricarboxylicacid,2-methoxy- (CAS 17445-86-2)
- 2-Methoxyphenylacetone (CAS 5211-62-1)
- N-Phenyl-beta-alanine Methyl Ester (CAS 21911-84-2)
- 2-Amino-3-[(methyl-d (CAS 1020719-03-2)
- (E)-2-(4-chlorobenzoyl)-3-(dimethylamino)acrylonitrile (CAS 52200-16-5)
- 2-(3,4-Dihydroisoquinolin-2(1H)-yl)-7-phenylthieno[3,2-d]pyrimidin-4-ol (CAS 1226441-61-7)
- 2804-50-4 A819298 [4,5-diacetyloxy-2-methyl-6-(6-oxidanylidene-3H-purin-9-yl)oxan-3-yl] ethanoate acetic acid [4,5-diacetyloxy-2-methyl-6-(6-oxo-3H-purin-9-yl)-3-oxanyl] ester (CAS 2804-50-4)
- Semaglutide impurity 257 (CAS CATO-C4X-2226257)
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