7-Bromo-2,6-dichloro-8-fluoro-4-(methylthio)quinazoline CAS 2857929-87-2

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 7-Bromo-2,6-dichloro-8-fluoro-4-(methylthio)quinazoline.

7-Bromo-2,6-dichloro-8-fluoro-4-(methylthio)quinazoline (CAS 2857929-87-2), molecular formula C9H4BrCl2FN2S and molecular weight 342.01 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of 7-Bromo-2,6-dichloro-8-fluoro-4-(methylthio)quinazoline (C9H4BrCl2FN2S) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine/chlorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 7-Bromo-2,6-dichloro-8-fluoro-4-(methylthio)quinazoline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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