Lotilaner Impurity 8 CAS CATO-C4X-32568
| CAS No. | CATO-C4X-32568 |
| Molecular Formula | C16H8Cl3F3O3S |
| Molecular Weight | 443.65 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C16H8Cl3F3O3S, Lotilaner Impurity 8 contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, a polycyclic aromatic system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 443.65 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Lotilaner Impurity 8 (CAS CATO-C4X-32568, C16H8Cl3F3O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Lotilaner Impurity 8 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H8Cl3F3O3S |
| Molecular Weight | 443.65 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Sulfur Atoms | 1 |
Related Lotilaner Standards
- Lotilaner Impurity 14 (CAS CATO-C4X-325614)
- Lotilaner Impurity 12 (CAS CATO-C4X-325612)
- Lotilaner Impurity 27 (E-Isomer) (CAS 2758907-88-7)
- Lotilaner Impurity 30 (Z-Isomer) (CAS 2758907-89-8)
- Lotilaner Impurity 13 (CAS CATO-C4X-325613)
- Lotilaner Impurity 2 (CAS CATO-C4X-32562)
- Lotilaner Impurity 19 (CAS CATO-C4X-325619)
- Lotilaner Impurity 26 (CAS 2758907-90-1)
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