Lotilaner Impurity 19 CAS CATO-C4X-325619
| CAS No. | CATO-C4X-325619 |
| Molecular Formula | C18H12Cl3F3O3S |
| Molecular Weight | 471.71 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Lotilaner Impurity 19 (C18H12Cl3F3O3S) is characterized by a steroid core, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, Lotilaner Impurity 19 (CAS CATO-C4X-325619, C18H12Cl3F3O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Lotilaner Impurity 19 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H12Cl3F3O3S |
| Molecular Weight | 471.71 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Sulfur Atoms | 1 |
Related Lotilaner Standards
- Lotilaner Impurity 26 (CAS 2758907-90-1)
- Lotilaner Impurity 3 (CAS CATO-C4X-32563)
- Lotilaner Impurity 6 (CAS CATO-C4X-32566)
- Lotilaner Impurity 9 (CAS CATO-C4X-32569)
- Lotilaner Impurity 16 (CAS CATO-C4X-325616)
- Lotilaner Impurity 5 (CAS 1613733-72-4)
- Lotilaner Impurity 13 (CAS CATO-C4X-325613)
- Lotilaner Impurity 2 (CAS CATO-C4X-32562)
Recommended Standards
- Di-tert-butyl (2-chloro-4-fluoro-3-iodophenyl)iminodicarbonate (CAS 2573784-37-7)
- 4-[(2Z)-3-(5-Bromo-2-methoxyphenyl)prop-2-enoyl]phenyl 4-chlorobenzoate (CAS 306730-28-9)
- Bis(2,2,2-trifluoroethyl) ((2-(2-amino-6-chloro-9H-purin-9-yl)ethoxy)methyl)phosphonate (CAS 186345-42-6)
- [2,5-Bis(2,2,2-trifluoroethoxy)phenyl]formamido 2-chlorobenzoate (CAS 338394-88-0)
- Risperidone EP Impurity K (CAS 106266-09-5)
- Olopatadine Impurity 28 (CAS 55453-89-9)
- Nintedanib Impurity 165 (CAS 1351810-29-1)
- 2-(Difluoromethyl)-6-hydroxy-5-(trifluoromethyl)pyridine-3-methanol (CAS 1805539-67-6)
- ethyl (R)-4-(3-(3-carbamoylphenyl)-2-((2,4,6-triisopropylphenyl)sulfonamido)propanoyl)piperazine-1-carboxylate (CAS CATO-C4X-33633)
- 2-(6-(4-(tert-Butyl)phenyl)pyridin-3-yl)acetonitrile (CAS 1192165-36-8)
- 3,3',4,5,5'-Pentabromobiphenyl (CAS 81902-33-2)
- 1-Methoxy-4-(3-(trifluoromethyl)phenyl)isoquinolin-5-ol (CAS 656234-01-4)
- 3-(3,5-Dimethylphenoxy)piperidine 4015AF 946681-15-8 C13H19NO (CAS 946681-15-8)
- (Tyr?)-C-Peptide (dog) (CAS 101135-67-5)
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