Clozapine impurity 9 CAS 27696-24-8
| CAS No. | 27696-24-8 |
| Molecular Formula | C13H12N2O2 |
| Molecular Weight | 228.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Clozapine impurity 9 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Clozapine impurity 9 (CAS 27696-24-8), a pharmacopoeial impurity reference standard (molecular formula C13H12N2O2, MW 228.25 g/mol) used for the identification and quantification of trace impurities in APIs.
Clozapine impurity 9 (C13H12N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C13H12N2O2 |
| Molecular Weight | 228.25 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Nitrogen Atoms | 2 |
Related Clozapine Standards
- Clozapine EP Impurity A (CAS 50892-62-1)
- Clozapine impurity 8 (CAS 5814-41-5)
- Clozapine Impurity 1 (CAS 5933-35-7)
- Clozapine impurity 10 (CAS 67990-66-3)
- Clozapine Impurity 1 (CAS 69414-55-7)
- Clozapine Impurity 11 (CAS CATO-C4X-134011)
- Clozapine EP Impurity C (CAS 6104-71-8)
- Clozapine Impurity 20 (CAS CATO-C4X-134020)
Recommended Standards
- Nafamostat impurity 126 (CAS CATO-C4X-1332126)
- Tranexamic Impurity 27 (CAS CATO-C4X-177127)
- Potassium Clavulanate impurity 22 (CAS 148601-26-7)
- Lenalidomide Impurity 29 (CAS 31140-42-8)
- Ruxolitinib Impurity 229 (CAS CATO-C4X-2058229)
- Ambroxol Impurity 83 (CAS CATO-C4X-108583)
- Moxifloxacin Impurity 89 (CAS 924-99-2)
- 2-Iodo-5-trifluoromethyl-4-trifluoromethylsulphanylpyridine (CAS 1408279-90-2)
- N-((5-((2-((2-Ethoxyphenyl)amino)-2-oxoethyl)thio)-1,3,4-oxadiazol-2-yl)methyl)furan-2-carboxamide (CAS 851862-52-7)
- 7,7-Dimethyl-5-oxo-5,6,7,8-tetrahydroquinoline-3-carbonitrile (CAS 135987-11-0)
- 2-(Trifluoromethyl)cyclopropan-1-amine hydrochloride (CAS 1172072-62-6)
- Methyl 2,6-dimethoxy-3-nitrobenzoate (CAS 55776-20-0)
- Pyrrolidine-2-carbothioamide (CAS 736911-49-2)
- D-Ala28-Tirzepatide (CAS CATO-CPTD788906)
Why CATO?
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