Clozapine impurity 10 CAS 67990-66-3
| CAS No. | 67990-66-3 |
| Molecular Formula | C13H11ClN2O2 |
| Molecular Weight | 262.69 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Clozapine impurity 10.
As a process- or degradation-related impurity, Clozapine impurity 10 (CAS 67990-66-3, C13H11ClN2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Clozapine impurity 10 (C13H11ClN2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 262.69 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Clozapine impurity 10 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C13H11ClN2O2 |
| Molecular Weight | 262.69 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Clozapine Standards
- Clozapine Impurity 1 (CAS 5933-35-7)
- Clozapine EP Impurity A (CAS 50892-62-1)
- Clozapine impurity 9 (CAS 27696-24-8)
- Clozapine Impurity 1 (CAS 69414-55-7)
- Clozapine Impurity 11 (CAS CATO-C4X-134011)
- Clozapine EP Impurity C (CAS 6104-71-8)
- Clozapine impurity 8 (CAS 5814-41-5)
- Clozapine Impurity 20 (CAS CATO-C4X-134020)
Recommended Standards
- Neratinib Impurity 56 (CAS CATO-C4X-113456)
- Norepinephrine Impurity 64 (CAS CATO-C4X-151464)
- 0448AF 4-[(2-Chlorobenzyl)oxy]benzoic acid 84403-78-1 C14H11ClO3 (CAS 84403-78-1)
- Roxadustat Impurity 81 (CAS CATO-C4X-221381)
- Levosimendan impurity 74 (CAS CATO-C4X-130874)
- Lansoprazole Impurity 20 (CAS CATO-C4X-111320)
- Formoterol Impurity 95 (CAS CATO-C4X-152595)
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- 2-(2-(Bromomethyl)pyrrolidin-1-yl)acetic acid (CAS 1353946-18-5)
- Ethyl aziridinyl formate (CAS 671-51-2)
- rac-(1R,2S)-2-methyl-2-(propan-2-yloxy)cyclopropan-1-amine hydrochloride (CAS 2059917-61-0)
- Fluoxetine (CAS 54910-89-3)
- Sperm Peptide P10G (H-2424.0001) (CAS 137353-73-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com