Edoxaban Impurity 65 CAS 2770688-74-7
| CAS No. | 2770688-74-7 |
| Molecular Formula | C16H22ClN5O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 463.93 g/mol gives Edoxaban Impurity 65 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Edoxaban Impurity 65 (CAS 2770688-74-7, C16H22ClN5O3CH4O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Edoxaban Impurity 65 (C16H22ClN5O3CH4O3S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 463.93 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H22ClN5O3 2*CH4O3S |
| Molecular Weight | 463.93 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2003 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Edoxaban Standards
- Edoxaban Impurity 73 (CAS 1057651-37-2)
- Edoxaban Impurity 7 (CAS 1072-98-6)
- Edoxaban Impurity 71 (CAS 1093351-29-1)
- Edoxaban Impurity N8 HCl (CAS 1190971-73-3)
- Edoxaban Impurity 47 (CAS 1210348-16-5)
- Edoxaban Impurity 74 (CAS 1210348-21-2)
- Edoxaban Impurity 20 (CAS 1210348-34-7)
- Edoxaban Tosylate Monohydrate (CAS 1229194-11-9)
Recommended Standards
- Atrasentan Impurity 78 (CAS 1058551-22-6)
- Relugolix Impurity 177 (CAS CATO-C4X-2429177)
- Linagliptin Impurity 58 (CAS CATO-C4X-110158)
- 4-(Allyloxy)-2-bromo-5-methoxybenzaldehyde (CAS 428496-25-7)
- 6-Chloro-4-fluoropicolinaldehyde (CAS 614752-51-1)
- 3-(1H-Indol-2-yl)phenol (CAS 40756-70-5)
- (2-(Benzyloxy)-4-ethyl-6-methylpyridin-3-yl)methanol (CAS 1616288-84-6)
- 2-(Benzyloxy)-3,5-diiodobenzaldehyde (CAS 306753-70-8)
- 1-Bromo-4-(1-cyclopropylvinyl)benzene (CAS 65322-32-9)
- (9-D-Asp) Semaglutide X Sodium salt (CAS CATO-CPTD788617)
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