Tofacitinib Impurity 136 CAS 2803420-43-9
| CAS No. | 2803420-43-9 |
| Molecular Formula | C20H24ClN5 |
| Molecular Weight | 369.89 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Tofacitinib Impurity 136.
Tofacitinib Impurity 136 (CAS 2803420-43-9) is a certified pharmaceutical impurity reference standard with the molecular formula C20H24ClN5 and a molecular weight of 369.89 g/mol.
Tofacitinib Impurity 136 (C20H24ClN5) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Tofacitinib Impurity 136 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H24ClN5 |
| Molecular Weight | 369.89 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2003 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Tofacitinib Standards
- Tofacitinib Impurity 134 (CAS CATO-C4X-1079134)
- Tofacitinib Impurity 135 (CAS CATO-C4X-1079135)
- Tofacitinib Impurity 214 (CAS CATO-C4X-1079214)
- Tofacitinib Impurity 223 (CAS CATO-C4X-1079223)
- Tofacitinib Impurity 31 (CAS 923036-25-3)
- Tofacitinib Impurity 229 (CAS CATO-C4X-1079229)
- Tofacitinib Impurity 202 (CAS CATO-C4X-1079202)
- Tofacitinib Impurity 51 (CAS 2504210-38-0)
Recommended Standards
- 4-((4-Chlorophenyl)thio)-2-(methylthio)-6-phenylpyrimidine-5-carbonitrile (CAS 341965-68-2)
- 4-((3-Chlorophenyl)thio)-2-(methylthio)-6-phenylpyrimidine-5-carbonitrile (CAS 341965-69-3)
- Trazodone impurity 51 (CAS CATO-C4X-177251)
- 3-(4-Benzylpiperazin-1-yl)-N-(4-chlorophenyl)but-2-enamide (CAS 867159-68-0)
- Ketoprofen Impurity 30 (CAS CATO-C4X-147130)
- Peficitinib Impurity 31 (CAS CATO-C4X-280731)
- Ertapenem Impurity 16 (CAS 266337-30-8)
- 5-Oxo-2,3,5,9b-tetrahydro-thiazolo-[2,3-a]isoindole-3-carboxylic acid (CAS 118726-68-4)
- 1-(4-Aminopiperidin-1-yl)-2-phenylethan-1-one (CAS 220463-38-7)
- (2,5-Dimethylphenyl)(oxazol-2-yl)methanone (CAS 898784-46-8)
- (4-(Difluoromethyl)pyrimidin-2-yl)methanamine (CAS 1784795-05-6)
- N-(4-BRomophenyl)-4-hydroxybenzamide (CAS 52189-56-7)
- N-Methoxy-1-(methylsulfonyl)azetidine-3-carboxamide (CAS 1448036-30-3)
- [y-Glu3]-Semaglutide Impurity 135 (CAS CATO-C4X-2226135)
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