Tofacitinib Impurity 31 CAS 923036-25-3
| CAS No. | 923036-25-3 |
| Molecular Formula | C20H24ClN5 |
| Molecular Weight | 369.89 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Tofacitinib Impurity 31 is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Tofacitinib Impurity 31 (CAS 923036-25-3) is a certified pharmaceutical impurity reference standard with the molecular formula C20H24ClN5 and a molecular weight of 369.89 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution, Tofacitinib Impurity 31 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 369.89 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H24ClN5 |
| Molecular Weight | 369.89 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Tofacitinib Standards
- Tofacitinib Impurity 134 (CAS CATO-C4X-1079134)
- Tofacitinib Impurity 135 (CAS CATO-C4X-1079135)
- Tofacitinib Impurity 136 (CAS 2803420-43-9)
- Tofacitinib Impurity 214 (CAS CATO-C4X-1079214)
- Tofacitinib Impurity 223 (CAS CATO-C4X-1079223)
- Tofacitinib Impurity 229 (CAS CATO-C4X-1079229)
- Tofacitinib Impurity 202 (CAS CATO-C4X-1079202)
- Tofacitinib Impurity 51 (CAS 2504210-38-0)
Recommended Standards
- Trazodone impurity 51 (CAS CATO-C4X-177251)
- 5-[[3-Chloro-4-(2-cyclohexylethoxy)phenyl]methylene]-2,4-thiazolidinedione-d4 (CAS 1795137-28-8)
- 6-(((4-Chlorobenzyl)thio)methyl)-N,N-dimethyl-2-phenylpyrimidin-4-amine (CAS 338961-74-3)
- 6-(((4-Chlorophenyl)thio)methyl)-2-phenyl-N-propylpyrimidin-4-amine (CAS 306980-49-4)
- Argatroban Impurity 108 (CAS CATO-C4X-1007108)
- Atorvastatin Impurity 132 (CAS 160449-60-5)
- Benzylpenicillin Impurity 53 (CAS CATO-C4X-189953)
- 4-(4-Bromophenyl)-3H-1,2,4-triazole-3,5(4H)-dione (CAS 107553-79-7)
- Methyl 3-amino-3-(2-chloro-3-methylphenyl)propanoate (CAS 1824403-22-6)
- 1-([1,2,4]Triazolo[4,3-b]pyridazin-6-yl)piperidin-4-amine (CAS 1525554-57-7)
- 3-Amino-8-(trifluoromethyl)bicyclo[3.2.1]octan-8-ol (CAS 1251924-77-2)
- N,n-bis(trimethylsilyl)-2,3,4,5,6-pentafluoroaniline (CAS 23188-59-2)
- Methyl 3-(3-fluorophenyl)-3-(2-(4-(4-fluorophenyl)piperazin-1-yl)acetamido)propanoate (CAS 860650-15-3)
- Semaglutide impurity 273 (CAS CATO-C4X-2226273)
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