Ruxolitinib Impurity 37 CAS 2821844-77-1
| CAS No. | 2821844-77-1 |
| Molecular Formula | C7H6ClN3O |
| Molecular Weight | 183.60 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Ruxolitinib Impurity 37 (CAS 2821844-77-1, C7H6ClN3O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to an amide group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, Ruxolitinib Impurity 37 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 183.60 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Ruxolitinib Impurity 37 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H6ClN3O |
| Molecular Weight | 183.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >85% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2003 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Ruxolitinib Standards
- Ruxolitinib Impurity 235 (CAS 82504-43-6)
- Ruxolitinib Impurity 46 (CAS 1236033-25-2)
- Ruxolitinib Impurity 147 (CAS 2761879-41-6)
- Ruxolitinib Impurity 187 (CAS CATO-C4X-2058187)
- Ruxolitinib Impurity 70 (CAS CATO-C4X-205870)
- Ruxolitinib Impurity 100 (CAS CATO-C4X-2058100)
- Ruxolitinib Impurity 190 (CAS CATO-C4X-2058190)
- Ruxolitinib Impurity 87 (CAS CATO-C4X-205887)
Recommended Standards
- 1-(chloromethoxy)-1H-benzo[d][1,2,3]triazole (CAS 3912-23-0)
- 2-(2-Chloro-4-fluoro-5-methylphenyl)acetonitrile (CAS 1000513-29-0)
- 8-Amino-6-chloro-3-methyl-[1,2,4]triazolo[4,3-b]pyridazine (CAS 53085-52-2)
- 3-(2-Chloro-6-fluorophenyl)propanenitrile (CAS 1057676-61-5)
- Sorafenib Impurity 28 (CAS CATO-C4X-112428)
- Semaglutide impurity 56 (CAS CATO-C4X-222656)
- L-Ornithine L-Aspartate Impurity 14 TFA Salt (CAS CATO-C4X-253614)
- 4,4'-Bipyrimidine (CAS 2426-94-0)
- VAL-083 (CAS 23261-20-3)
- 1,8-Dioxaspiro[4.5]dec-2-en-4-one (CAS 2138297-68-2)
- 2-(Trifluoromethoxy)propanoic acid (CAS 1378795-51-7)
- 1,2-Dibromo-3-difluoromethoxy-5-(trifluoromethylthio)benzene (CAS 1803775-20-3)
- Ethyl 4-fluoro-4-methyl-2-pent-4-enamidopentanoate (CAS 1000995-94-7)
- Semaglutide impurity 26 (CAS CATO-C4X-222626)
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