Ruxolitinib Impurity 46 CAS 1236033-25-2
| CAS No. | 1236033-25-2 |
| Molecular Formula | C7H8ClN3O |
| Molecular Weight | 185.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ruxolitinib Impurity 46 is closely related to an amide group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Ruxolitinib Impurity 46 (CAS 1236033-25-2, C7H8ClN3O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Ruxolitinib Impurity 46 (C7H8ClN3O) contains an amide group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Ruxolitinib Impurity 46 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H8ClN3O |
| Molecular Weight | 185.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Ruxolitinib Standards
- Ruxolitinib Impurity 235 (CAS 82504-43-6)
- Ruxolitinib Impurity 37 (CAS 2821844-77-1)
- Ruxolitinib Impurity 147 (CAS 2761879-41-6)
- Ruxolitinib Impurity 187 (CAS CATO-C4X-2058187)
- Ruxolitinib Impurity 70 (CAS CATO-C4X-205870)
- Ruxolitinib Impurity 100 (CAS CATO-C4X-2058100)
- Ruxolitinib Impurity 190 (CAS CATO-C4X-2058190)
- Ruxolitinib Impurity 87 (CAS CATO-C4X-205887)
Recommended Standards
- Pyridoxine impurity 89 (CAS CATO-C4X-187789)
- Aminomethylbenzoic Acid Impurity 4 (CAS 165530-43-8)
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- Flunixin Meglumine EP Impurity C (CAS 1452-94-4)
- Cabazitaxel Impurity 2 (CAS 160084-81-1)
- Sertraline Impurity 60 (CAS CATO-C4X-134460)
- Nortropine Impurity 2 (CAS 30833-12-6)
- Methyl 1-(3-ethoxy-1-ethyl-1H-pyrazole-4-carbonyl)piperidine-4-carboxylate (CAS 1014027-09-8)
- 2-(Benzyloxy)-6-(nitromethyl)benzonitrile (CAS 79966-73-7)
- 3-Chloro-4-(4-methylphenoxy)aniline (CAS 56966-55-3)
- 3-(3-Chlorophenyl)-5-(2-hydrazinylpyridin-3-yl)-1,2,4-oxadiazole (CAS 1232788-06-5)
- N-(4-oxo-2-thioxo-3-thiazolidinyl)-3-Pyridinecarboxamide hydrochloride (1:1) (CAS 353505-83-6)
- 2-(4-Bromo-1-methyl-1H-pyrazol-5-yl)-6-cyclopropoxy-4-(trifluoromethyl)benzonitrile (CAS 2629317-41-3)
- Hexapeptide-10 (CAS 146439-94-3)
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