Baclofen impurity 10 CAS 28311-33-3
| CAS No. | 28311-33-3 |
| Molecular Formula | C10H12ClNO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Baclofen impurity 10 (CAS 28311-33-3) is a certified pharmaceutical impurity reference standard with the molecular formula C10H12ClNO2HCl and a molecular weight of 250.12 g/mol.
Structurally, Baclofen impurity 10 (C10H12ClNO2HCl) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 250.12 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Baclofen impurity 10 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H12ClNO2 HCl |
| Molecular Weight | 250.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1965 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Baclofen Standards
- Baclofen impurity 9 (CAS 101104-10-3)
- Baclofen impurity 42 (CAS 101466-69-7)
- Baclofen impurity 7 (CAS 103857-58-5)
- Baclofen Impurity 5 (CAS 1053068-98-6)
- Baclofen Impurity 34 Hydrochloride (CAS 1078-21-3（free base）)
- Baclofen (CAS 1134-47-0)
- Baclofen EP Impurity B (CAS 1141-23-7)
- Baclofen impurity 17 (CAS 114703-75-2)
Recommended Standards
- Ipratropium Impurity 23 (CAS CATO-C4X-166523)
- Rocuronium Impurity 75 (CAS CATO-C4X-124275)
- Avatrombopag Impurity 95 (CAS CATO-C4X-223495)
- 5-(2-Chloro-6-fluorophenyl)-4-(1H-1,2,4-triazol-1-yl)cyclohexane-1,3-dione (CAS 439121-24-1)
- (S)-1-(3-bromo-5-methylphenyl)-2-methoxyethan-1-amine (CAS 1269939-47-0)
- 1,2,6,7-Tetrahydroimidazo[2,1-c][1,2,4]triazin-3(4H)-one (CAS 62638-42-0)
- 2-(4-methylpiperazin-1-yl)acetamide (CAS 83808-21-3)
- 1,3-Bis(4-bromophenyl)-2-chloropropane-1,3-dione (CAS 937602-10-3)
- N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)heptan-1-amine hydrochloride (CAS 1856042-25-5)
- 30003-72-6 insulin chain b oxidized (CAS 30003-72-6)
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