Baclofen impurity 9 CAS 101104-10-3
| CAS No. | 101104-10-3 |
| Molecular Formula | C15H19ClO4 |
| Molecular Weight | 298.76 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Baclofen impurity 9 (CAS 101104-10-3) is a certified pharmaceutical impurity reference standard with the molecular formula C15H19ClO4 and a molecular weight of 298.76 g/mol.
The molecular framework of Baclofen impurity 9 (C15H19ClO4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H19ClO4 |
| Molecular Weight | 298.76 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
Related Baclofen Standards
- Baclofen Impurity 65 (CAS CATO-C4X-101265)
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Recommended Standards
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- Ethyl 6-(5-chloro-2-methoxyphenyl)-6-oxohexanoate (CAS 951886-73-0)
- Lornoxicam impurity 67 (CAS CATO-C4X-201667)
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- D-Galactosamine Hydrochloride (CAS 1772-03-8)
- 1-Allyl-6-bromo-1H-benzo[d][1,3]oxazine-2,4-dione (CAS 1131587-69-3)
- (2R,3R,4R)-4-((tert-butyldiphenylsilyl)oxy)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-3,4-dihydro-2H-pyran-3-yl acetate (CAS 308103-44-8)
- 3-Amino-2-(2-chloro-6-fluorophenyl)propan-1-ol (CAS 1368489-12-6)
- methyl 1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate (CAS 7442-52-6)
- Semaglutide impurity 261 (CAS CATO-C4X-2226261)
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