Bumetanide EP Impurity B CAS 28328-54-3
| CAS No. | 28328-54-3 |
| Molecular Formula | C13H12N2O5S |
| Molecular Weight | 308.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Bumetanide EP Impurity B (CAS 28328-54-3), a pharmacopoeial impurity reference standard (molecular formula C13H12N2O5S, MW 308.31 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, Bumetanide EP Impurity B is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 308.31 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H12N2O5S |
| Molecular Weight | 308.31 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1965 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Bumetanide Standards
- Bumetanide Impurity 74 (CAS CATO-C4X-198674)
- Bumetanide Impurity 22 (CAS CATO-C4X-198622)
- Bumetanide Impurity 76 (CAS CATO-C4X-198676)
- Bumetanide Impurity 12 (CAS 22893-29-4)
- Bumetanide Impurity 65 (CAS CATO-C4X-198665)
- Bumetanide Impurity 57 (CAS CATO-C4X-198657)
- Bumetanide Impurity 66 (CAS CATO-C4X-198666)
- Bumetanide Impurity 32 (CAS 22892-95-1)
Recommended Standards
- trans Resveratrol-4'-sulfate (CAS 858187-19-6)
- Nimesulide (CAS 51803-78-2)
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- 5-Benzoyl-4-Hydroxy-2-Methoxybenzenesulfonic Acid (CAS 4065-45-6)
- Perampanel impurity 43 (CAS CATO-C4X-243043)
- Valsartan Impurity 142 (CAS CATO-C4X-1057142)
- Suzetrigine Impurity 10 (CAS 3083233-56-8)
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- 3-Chloro-4-fluoro-2-methylaniline (CAS 1357930-39-2)
- 2,4-Bis(benzyloxy)-6-chloropyrimidine (CAS 71885-71-7)
- (S)-2,5-Dioxopyrrolidin-1-yl 2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-oxo-4-(tritylamino)butanoate (CAS 856170-50-8)
- 5,5'-(((Perfluoropropane-2,2-diyl)bis(4,1-phenylene))bis(oxy))bis(isobenzofuran-1,3-dione) (CAS 61778-79-8)
- 5'-Benzyl 1-(tert-butyl) (3a'R,6a'R)-3'-oxohexahydro-5'H-spiro[piperidine-4,1'-pyrrolo[3,4-c]pyrrole]-1,5'-dicarboxylate (CAS 1951442-13-9)
- Liraglutide Impurity 6 TFA Salt (CAS CATO-C4X-19926)
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