Sorafenib Impurity 18 CAS 284461-74-1
| CAS No. | 284461-74-1 |
| Molecular Formula | C20H14ClF3N4O3 |
| Molecular Weight | 450.80 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Sorafenib Impurity 18 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Sorafenib Impurity 18 (CAS 284461-74-1, C20H14ClF3N4O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Sorafenib Impurity 18 (C20H14ClF3N4O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C20H14ClF3N4O3 |
| Molecular Weight | 450.80 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Sorafenib Standards
- Sorafenib Impurity 16 (CAS 1012058-78-4)
- Sorafenib Impurity 38 (CAS 862875-16-9)
- Sorafenib (Base) (CAS 284461-73-0)
- Sorafenib Impurity 40 (CAS 1290546-48-3)
- Sorafenib Impurity 42 (CAS CATO-C4X-112442)
- Sorafenib EP Impurity H (CAS 1431697-81-2)
- Sorafenib related compound 26 (CAS 573673-43-5)
- Sorafenib Related Compound 28 (CAS 583840-04-4)
Recommended Standards
- tert-Butyl 4-(4-bromophenyl)-4-(4-chlorophenyl)-piperidine-1-carboxylate (CAS 857532-23-1)
- Ethyl 2-(((3-chloro-5-(trifluoromethyl)pyridin-2-yl)thio)methyl)-4-(trifluoromethyl)thiazole-5-carboxylate (CAS 1823184-40-2)
- N-[2-({[(dimethylcarbamothioyl)disulfanyl]methanethioyl}amino)ethyl][(dimethylcarbamothioyl)disulfanyl]carbothioamide (CAS 5836-23-7)
- 4-((3-Chloro-4-hydroxybenzoyl)oxy)naphthalen-2-yl 3,4-dihydroxybenzoate (CAS 1449468-52-3)
- Telmisartan Impurity 78 (CAS CATO-C4X-135978)
- Aztreonam impurity 66 (CAS CATO-C4X-152266)
- Droperidol Impurity 11 (CAS CATO-C4X-276911)
- 5-(2-Chloronicotinoyl)-2-furoic acid (CAS 914203-45-5)
- 4-[4-(Trifluoromethyl)phenyl]piperidine Hydrochloride (CAS 574008-73-4)
- tert-Butyl 4-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indoline-1-carboxylate (CAS 1337533-32-0)
- Ethyl 2-(((1-(4-fluorophenyl)-1H-tetrazol-5-yl)methyl)amino)-2-oxoacetate (CAS 921060-06-2)
- 6-Methyl-3-azabicyclo[4.1.0]heptane Hydrochloride (CAS 910789-29-6)
- 1-Benzyl-1,3-benzodiazol-4-amine (CAS 155242-92-5)
- Semaglutide impurity 69 (CAS CATO-C4X-222669)
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