Sofosbuvir impurity 123 CAS 2875067-01-7
| CAS No. | 2875067-01-7 |
| Molecular Formula | C14H13F5O3 |
| Molecular Weight | 324.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Sofosbuvir impurity 123.
As a process- or degradation-related impurity, Sofosbuvir impurity 123 (CAS 2875067-01-7, C14H13F5O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, Sofosbuvir impurity 123 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 324.24 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Sofosbuvir impurity 123 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H13F5O3 |
| Molecular Weight | 324.24 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2003 |
| Halogen Content | F-containing |
Related Sofosbuvir Standards
- Sofosbuvir impurity 122 (CAS 3041980-48-4)
- Sofosbuvir impound 124 (CAS 2875066-41-2)
- Sofosbuvir Impurity 44 (CAS 879551-01-6)
- Sofosbuvir Impurity 99 (CAS CATO-C4X-105299)
- Sofosbuvir Impurity 50 (CAS 1015073-43-4)
- Sofosbuvir Impurity 98 (CAS 111955-47-6)
- Sofosbuvir Impurity 67 (CAS CATO-C4X-105267)
- Sofosbuvir Impurity 52 (CAS 1520010-86-9)
Recommended Standards
- 5-(3,5-Bis(trifluoromethyl)phenyl)thiophene-2-carbaldehyde (CAS 887986-61-0)
- Methotrexate EP Impurity L (CAS CATO-C4X-115415)
- 2-Bromo-N-(1-(thiophen-2-yl)propan-2-yl)benzamide (CAS 717120-96-2)
- Suzetrigine Impurity 13 (CAS CATO-C4X-336913)
- Lipoic acid impurity N1 (CAS 17370-41-1)
- Cefotiam Impurity 3 (CAS CATO-C4X-12043)
- Metaraminol Impurity 99 (CAS CATO-C4X-225299)
- 1-(Dimethylamino)-3-(3-methoxyphenyl)-2-methylpentan-3-ol (CAS 433936-13-1)
- 6-Bromo-2-isopropylisoquinolin-1(2H)-one (CAS 864867-02-7)
- 7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one (CAS 1312005-59-6)
- 2,2,2-Trifluoro-N-(1H-indazol-6-yl)acetamide (CAS 1379290-04-6)
- N-(sec-Butyl)-6-chloropyridazin-3-amine (CAS 62040-02-2)
- 4-Methyl-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazole-3-thiol (CAS 77803-41-9)
- 30003-72-6 insulin chain b oxidized (CAS 30003-72-6)
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