Sofosbuvir impound 124 CAS 2875066-41-2
| CAS No. | 2875066-41-2 |
| Molecular Formula | C14H15F5O3 |
| Molecular Weight | 326.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Sofosbuvir impound 124 (C14H15F5O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 326.26 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Sofosbuvir impound 124 (CAS 2875066-41-2) is a certified pharmaceutical impurity reference standard with the molecular formula C14H15F5O3 and a molecular weight of 326.26 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H15F5O3 |
| Molecular Weight | 326.26 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2003 |
| Halogen Content | F-containing |
Related Sofosbuvir Standards
- Sofosbuvir impurity 122 (CAS 3041980-48-4)
- Sofosbuvir impurity 123 (CAS 2875067-01-7)
- Sofosbuvir Impurity 99 (CAS CATO-C4X-105299)
- Sofosbuvir Impurity 50 (CAS 1015073-43-4)
- Sofosbuvir Impurity 98 (CAS 111955-47-6)
- Sofosbuvir Impurity 44 (CAS 879551-01-6)
- Sofosbuvir Impurity 67 (CAS CATO-C4X-105267)
- Sofosbuvir Impurity 91 (CAS 817204-35-6)
Recommended Standards
- Diacerein EP Impurity D (CAS 875535-35-6)
- Apremilast Impurity 70 (CAS CATO-C4X-100970)
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