Losartan Impurity 42 CAS 2901098-91-5
| CAS No. | 2901098-91-5 |
| Molecular Formula | C14H10BrN |
| Molecular Weight | 272.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Losartan Impurity 42 (CAS 2901098-91-5) is a certified pharmaceutical impurity reference standard with the molecular formula C14H10BrN and a molecular weight of 272.14 g/mol.
The molecular framework of Losartan Impurity 42 (C14H10BrN) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C14H10BrN |
| Molecular Weight | 272.14 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2004 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Losartan Standards
- Losartan Impurity 43 (CAS 135689-84-8)
- Losartan EP Impurity B (CAS 160514-13-6)
- Losartan Impurity 62 (CAS CATO-C4X-168362)
- Losartan Potassium EP Impurity E (CAS 120568-11-8)
- Losartan Impurity 47 (CAS CATO-C4X-168347)
- Losartan Impurity 63 (CAS CATO-C4X-168363)
- Losartan Impurity 20 (CAS 154709-19-0)
- Losartan Impurity 58 (CAS CATO-C4X-168358)
Recommended Standards
- Carbamazepine Impurity 13 (CAS 75272-34-3)
- Valsartan Impurity 97 (CAS CATO-C4X-105797)
- Niraparib Impurity 49 (CAS 1267209-15-3)
- Valsartan Impurity 96 (CAS CATO-C4X-105796)
- Cefotiam Impurity 53 (CAS CATO-C4X-120453)
- Clopidogrel Impurity 44 (CAS CATO-C4X-102944)
- Eltrombopag Impurity 92 (CAS CATO-C4X-119892)
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