Avatrombopag Impurity 59 CAS 2948773-23-5

Description

Compared with other compounds in its class, the molecular weight of 1014.61 g/mol gives Avatrombopag Impurity 59 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

Avatrombopag Impurity 59 (CAS 2948773-23-5) is a certified pharmaceutical impurity reference standard with the molecular formula C46H55Cl3N10O2S4 and a molecular weight of 1014.61 g/mol.

Avatrombopag Impurity 59 (C46H55Cl3N10O2S4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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