Ruxolitinib Impurity 11 CAS 2950130-23-9
| CAS No. | 2950130-23-9 |
| Molecular Formula | C18H21N5O2 |
| Molecular Weight | 339.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ruxolitinib Impurity 11.
Ruxolitinib Impurity 11 (CAS 2950130-23-9) is a certified pharmaceutical impurity reference standard with the molecular formula C18H21N5O2 and a molecular weight of 339.39 g/mol.
Based on its molecular formula C18H21N5O2, Ruxolitinib Impurity 11 contains a steroid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 339.39 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H21N5O2 |
| Molecular Weight | 339.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2004 |
| Nitrogen Atoms | 5 |
Related Ruxolitinib Standards
- Ruxolitinib Impurity 84 (CAS CATO-C4X-205884)
- Ruxolitinib Impurity 140 (CAS 1289219-47-1)
- Ruxolitinib Impurity 73 (CAS CATO-C4X-205873)
- Ruxolitinib Impurity 231 (CAS CATO-C4X-2058231)
- Ruxolitinib Impurity 99 (CAS CATO-C4X-205899)
- Ruxolitinib Impurity 22 (CAS CATO-C4X-205822)
- Ruxolitinib Impurity 4 (CAS 1236033-03-6)
- Ruxolitinib Impurity 7 (CAS CATO-C4X-20587)
Recommended Standards
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- Safinamide impurity 02 (CAS 65581-83-1)
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- 2-[(2-Benzimidazolyl)methyl]benzothiazole (CAS 66557-64-0)
- 3-Hydroxystanozolol glucuronide (CAS 361432-41-9)
- 1H-Benzimidazole, 1-(4-piperidinylmethyl) (CAS 852627-74-8)
- 6-Amino-4-(4-chlorophenyl)-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile (CAS 76973-35-8)
- Methyl 4-Chloroquinazoline-5-carboxylate (CAS 1260890-93-4)
- Cefuroxime Sodium EP Impurity F (CAS 97170-19-9)
- Peptide Impurity 06 (CAS CATO-CPTD788806)
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