Crisaborole Impurity 144 CAS CATO-C4X-2021144
| CAS No. | CATO-C4X-2021144 |
| Molecular Formula | C21H22BNO5 |
| Molecular Weight | 379.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Crisaborole Impurity 144.
CATO supplies Crisaborole Impurity 144 (CAS CATO-C4X-2021144), a pharmacopoeial impurity reference standard (molecular formula C21H22BNO5, MW 379.21 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C21H22BNO5, Crisaborole Impurity 144 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 379.21 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H22BNO5 |
| Molecular Weight | 379.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Crisaborole Standards
- Crisaborole Impurity 22 (CAS CATO-C4X-202122)
- Crisaborole impurity 160 (CAS CATO-C4X-2021160)
- Crisaborole impurity 109 (CAS CATO-C4X-2021109)
- Crisaborole Impurity 103 (CAS CATO-C4X-2021103)
- Crisaborole impurity 119 (CAS CATO-C4X-2021119)
- Crisaborole Impurity 147 (CAS CATO-C4X-202147)
- Crisaborole Impurity 56 (CAS CATO-C4X-202156)
- Crisaborole lmpurity 68 (CAS 943311-78-2)
Recommended Standards
- N-[6-(4-Bromophenyl)-3,4,5-tricyano-2-pyridinyl]-N,N-dimethyliminoformamide (CAS 478081-34-4)
- Deflazacort Impurity 90 (CAS CATO-C4X-202190)
- n-(1,1-Dioxidotetrahydrothiophen-3-yl)-3-iodo-N-methylbenzamide (CAS 931065-76-8)
- 5,7-Dichloro-N-(3-fluorophenyl)thiazolo[4,5-d]pyrimidine-2-sulfonamide (CAS 1000576-41-9)
- Ketoprofen Impurity 40 (CAS 47087-07-0)
- Norfloxacin Impurity 4 (CAS 75073-15-3)
- Clindamycin Phosphate Impurity 12 HCl (CAS 1800297-64-6)
- (1R,3r)-3-cyclopentylcyclobutan-1-amine (CAS 2359265-02-2)
- 4-Chloro-5-fluoro-2-methylquinoline (CAS 1799421-05-8)
- 1-(4-Bromophenyl)-2,2-dimethylpropan-1-ol (CAS 73492-35-0)
- 175277-30-2 3-chloranyl-2-methyl-5-(trifluoromethyl)pyridine 3-chloro-2-methyl-5-(trifluoromethyl)pyridine A812002 (CAS 175277-30-2)
- (5-Fluoro-2-propoxyphenyl)(methyl)sulfane (CAS 1379351-13-9)
- Ganciclovir EP Impurity F (CAS 73-40-5)
- Akt/SKG Substrate Peptide (CAS 276680-69-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com