Sacubitril impurity 48 CAS 2984580-04-1
| CAS No. | 2984580-04-1 |
| Molecular Formula | C25H31NO5 |
| Molecular Weight | 425.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, Sacubitril impurity 48 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 425.52 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Sacubitril impurity 48 (CAS 2984580-04-1) is a certified pharmaceutical impurity reference standard with the molecular formula C25H31NO5 and a molecular weight of 425.52 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Sacubitril impurity 48 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H31NO5 |
| Molecular Weight | 425.52 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2004 |
| Nitrogen Atoms | 1 |
Related Sacubitril Standards
- Sacubitril Impurity 20 (CAS 2459446-51-4)
- Sacubitril Impurity 37 (CAS CATO-C4X-280937)
- Sacubitril impurity 19 (CAS CATO-C4X-280919)
- Sacubitril-d4 (CAS 1884269-07-1)
- Sacubitril Impurity 29 (CAS CATO-C4X-280929)
- Sacubitril Impurity 32 (CAS CATO-C4X-280932)
- Sacubitril impurity 45 (CAS 761373-05-1)
- Sacubitril impurity 54 (CAS 149709-63-7)
Recommended Standards
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- Absorbent UV-1577 (CAS 147315-50-2)
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- Tizanidine Impurity 36 (CAS CATO-C4X-144537)
- Dihydroergocristine Mesilate EP Impurity A (CAS 2410-19-7)
- tert-Butyl 5-cyanoisoxazole-3-carboxylate (CAS 2112671-44-8)
- (3R)-3-amino-3-(4-nitrophenyl)propan-1-ol (CAS 1213310-15-6)
- 3-(Aminomethyl)pyridine-2,4,5,6-d (CAS 1020719-00-9)
- Ethyl 4,4-diethoxy-3-oxobutanoate (CAS 10495-09-7)
- Methyl (1R,2R)-2-(hydroxymethyl)cyclohexane-1-carboxylate (CAS 71550-80-6)
- 6-Amino-4,5-dihydropyridin-2(3H)-one (CAS 99418-74-3)
- Palmitoyl Tripeptide-1 HCl (CAS 2757690-14-3)
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