Timolol Impurity 14 CAS 58827-68-2
| CAS No. | 58827-68-2 |
| Molecular Formula | C9H13N3O3S |
| Molecular Weight | 243.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Timolol Impurity 14 (CAS 58827-68-2, C9H13N3O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Timolol Impurity 14 (C9H13N3O3S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Timolol Impurity 14 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H13N3O3S |
| Molecular Weight | 243.28 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Timolol Standards
- Timolol Impurity 7 (CAS 30315-49-2)
- Timolol EP Impurity F (CAS 30165-96-9)
- Timolol EP Impurity G (K salt) (CAS 79844-78-3)
- Timolol EP Impurity G (CAS 75202-36-7)
- Timolol EP Impurity I (CAS 2469037-77-0)
- Timolol EP Impurity I (CAS CATO-C4X-149611)
- Timolol Impurity 2 (CAS 75014-26-5)
- Timolol EP Impurity D (CAS 30165-97-0)
Recommended Standards
- Gliclazide EP Impurity C (CAS 5577-13-9)
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- Flurbiprofen impurity 120 (CAS 87657-78-1)
- Lifitegrast Impurity 96 (CAS 1270093-99-6)
- Apixaban Impurity 134 (CAS CATO-C4X-1088134)
- Obeticholic Acid Impurity 14 (CAS CATO-C4X-115314)
- Saxagliptin Impurity 40 (CAS 361442-00-4)
- tert-Butyl 6-bromo-3-chloropicolinate (CAS 1824285-91-7)
- 3-(3,4-Difluorophenyl)-3-oxopropanal (CAS 913820-49-2)
- 6-methylpyridine-3-sulfonyl chloride (CAS 478264-00-5)
- 2-Methyl-1-(trifluoromethyl)naphthalene (CAS 70109-82-9)
- (Z)-3-(dimethylamino)-2-methyl-Acrylonitrile (CAS 28976-80-9)
- 4-ethoxy-1,1,1-trifluoro-3-buten-2-one (CAS 17129-06-5)
- D-Ile17-Tirzepatide (CAS CATO-CPTD788917)
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