Timolol EP Impurity G CAS 75202-36-7
| CAS No. | 75202-36-7 |
| Molecular Formula | C6H9N3O3S |
| Molecular Weight | 203.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Timolol EP Impurity G.
Timolol EP Impurity G (CAS 75202-36-7) is a certified pharmaceutical impurity reference standard with the molecular formula C6H9N3O3S and a molecular weight of 203.22 g/mol.
Timolol EP Impurity G (C6H9N3O3S) contains an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H9N3O3S |
| Molecular Weight | 203.22 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Timolol Standards
- Timolol EP Impurity G (K salt) (CAS 79844-78-3)
- Timolol EP Impurity F (CAS 30165-96-9)
- Timolol EP Impurity D (CAS 30165-97-0)
- Timolol Impurity 27 (CAS CATO-C4X-149627)
- Timolol Impurity 16 (CAS 214691-24-4)
- Timolol Impurity 7 (CAS 30315-49-2)
- Timolol Impurity 14 (CAS 58827-68-2)
- Timolol Impurity 15 (CAS 949293-84-9)
Recommended Standards
- Torasemide impurity 36 (CAS CATO-C4X-183636)
- Pyrido[3,2:4,5]thieno[3,2-d]pyrimidin-4(3H)-one (CAS 55115-79-2)
- Dotinurad Impurity 193 (CAS CATO-C4X-2494193)
- N2-(4-Fluorophenyl)-2,3-pyridinediamine (CAS 41010-70-2)
- Enarodustat Impurity 21 (CAS CATO-C4X-322821)
- Pitavastatin Impurity 104 (CAS CATO-C4X-1037104)
- Tofacitinib Impurity N48 (CAS 1638499-35-0)
- 912771-31-4 1-(1,3-Dimethylpyrrolidin-3-yl)methanamine DTXSID80595787 (CAS 912771-31-4)
- 5-(3-(Trifluoromethyl)phenyl)nicotinamide (CAS 1356111-05-1)
- (1S,2R)-2-(Pyrrolidin-1-yl)cyclohexan-1-amine (CAS 133575-75-4)
- 3-Methyl-5-(phenylethynyl)pyridin-2-amine (CAS 1823291-91-3)
- di(2,2,3,3,4,4,5,5,5-nonafluoropentyl) 9H-fluorene-2,7-disulphonate (CAS 254900-51-1)
- (1R,2R)-2-(4-Bromophenyl)cyclopropanecarboxylic Acid (CAS 31501-85-6)
- Des-His(1)-Semaglutide (CAS CATO-C4X-2226216)
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