1-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}ethyl)-3-[(4-chlorophenyl)sulfanyl]pyrrolidine-2,5-dione CAS 303151-59-9
| CAS No. | 303151-59-9 |
| Molecular Formula | C18H14Cl2F3N3O2S |
| Molecular Weight | 464.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 1-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}ethyl)-3-[(4-chlorophenyl)sulfanyl]pyrrolidine-2,5-dione (C18H14Cl2F3N3O2S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
1-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}ethyl)-3-[(4-chlorophenyl)sulfanyl]pyrrolidine-2,5-dione (CAS 303151-59-9), molecular formula C18H14Cl2F3N3O2S and molecular weight 464.29 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}ethyl)-3-[(4-chlorophenyl)sulfanyl]pyrrolidine-2,5-dione meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H14Cl2F3N3O2S |
| Molecular Weight | 464.29 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related chloro Standards
- 2-[3-(2-Chloro-6-fluorophenyl)-4-methyl-1,2-oxazol-5-yl]-7-(4-chlorophenyl)-[1,2,4]triazolo[1,5-a]pyridine-8-carbonitrile (CAS 860611-27-4)
- (Z)-({1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-indol-3-yl}methylidene)[(4-chlorophenyl)methoxy]amine (CAS 338410-01-8)
- 3-Chloro-N-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)thio)-2-methylpropyl)-5-(trifluoromethyl)pyridin-2-amine (CAS 321432-61-5)
- 5-Chloro-3-(((4-chlorophenyl)thio)methyl)-4-(((2,3-dichlorophenyl)thio)methyl)-1-methyl-1H-pyrazole (CAS 318234-37-6)
- 5-Chloro-3-(((4-chlorophenyl)thio)methyl)-4-(((2,4-dichlorophenyl)thio)methyl)-1-methyl-1H-pyrazole (CAS 318234-36-5)
- 5-Chloro-3-(((4-chlorophenyl)thio)methyl)-4-(((2,6-dichlorophenyl)thio)methyl)-1-methyl-1H-pyrazole (CAS 318234-30-9)
- 1-(4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-2-((4-chlorophenyl)thio)propan-1-one (CAS 634155-05-8)
- 3-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]oxy}phenyl 2-chlorobenzenesulfonate (CAS 339026-70-9)
Recommended Standards
- Ethyl 4-iodo-3-(trifluoromethyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-5-carboxylate (CAS 2883431-36-3)
- 2-(4-Bromophenyl)-6-methyl-1-[4-(trifluoromethoxy)phenyl]-4,5,6,7-tetrahydro-1H-indol-4-one (CAS 1024400-40-5)
- [1-(3,4-dichlorobenzoyl)-4-fluoro-4-piperidinyl]methyl 4-fluorobenzenesulfonate (CAS 477857-55-9)
- Etravirine Iimpurity 8 (CAS CATO-C4X-13568)
- 4-(1H-Imidazol-1-yl)pyrimidine (CAS 183552-82-1)
- N-(Butan-2-yl)-4-(5-chloro-2-methylphenyl)piperazine-1-carboxamide (CAS 1023843-27-7)
- (S)-2-Amino-N-((3-(methylthio)pyrazin-2-yl)methyl)propanamide (CAS 1353995-60-4)
- 6,9-Dimethyl-3-oxa-1-azaspiro[4.5]dec-1-en-2-amine (CAS 1561916-07-1)
- 6-Methyl-2-phenylbenzoic acid (CAS 92254-02-9)
- 4-Chloro-2-cyclopropyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine (CAS 1247618-11-6)
- N-Butyl-4-Bromobenzamide (CAS 78080-34-9)
- 1-(sec-Butyl)-N-((1-ethyl-1H-pyrazol-5-yl)methyl)-1H-pyrazol-3-amine hydrochloride (CAS 1855946-61-0)
- 6-bromo-5-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one (CAS 116035-73-5)
- Semaglutide impurity 49 (CAS CATO-C4X-222649)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com