Roflumilast USP Related Compound E CAS 3031785-18-6
| CAS No. | 3031785-18-6 |
| Molecular Formula | C17H14BrClF2N2O3 |
| Molecular Weight | 447.66 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Roflumilast USP Related Compound E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Roflumilast USP Related Compound E (CAS 3031785-18-6) is a high-purity analytical reference standard with the molecular formula C17H14BrClF2N2O3 and a molecular weight of 447.66 g/mol.
The molecular framework of Roflumilast USP Related Compound E (C17H14BrClF2N2O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C17H14BrClF2N2O3 |
| Molecular Weight | 447.66 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2005 |
| Halogen Content | F/Cl/Br-containing |
| Nitrogen Atoms | 2 |
Related Roflumilast Standards
- Roflumilast Impurity 54 (CAS CATO-C4X-108454)
- Roflumilast Impurity 35 (CAS CATO-C4X-108435)
- Roflumilast-D4 N-Oxide (CAS 1794760-31-8)
- Roflumilast N-Oxide (CAS 292135-78-5)
- Roflumilast Impurity 39 (CAS CATO-C4X-108439)
- Roflumilast Impurity 59 (CAS CATO-C4X-193559)
- Roflumilast Impurity 6 (CAS 2368178-29-2)
- Roflumilast Impurity 3 (CAS 1391052-24-6)
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