Ethyl 5-amino-1-(2-fluorophenyl)-1H-pyrazole-3-carboxylate CAS 304874-05-3
| CAS No. | 304874-05-3 |
| Molecular Formula | C12H12FN3O2 |
| Molecular Weight | 249.24 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Ethyl 5-amino-1-(2-fluorophenyl)-1H-pyrazole-3-carboxylate (CAS 304874-05-3), molecular formula C12H12FN3O2 and molecular weight 249.24 g/mol, is a CATO reference standard with documented purity and traceability.
Ethyl 5-amino-1-(2-fluorophenyl)-1H-pyrazole-3-carboxylate (C12H12FN3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Ethyl 5-amino-1-(2-fluorophenyl)-1H-pyrazole-3-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H12FN3O2 |
| Molecular Weight | 249.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Ethyl Standards
- Ethyl 5-amino-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylate (CAS 1264046-99-2)
- Ethyl 5-amino-1-(3-fluorophenyl)-1H-pyrazole-3-carboxylate (CAS 1264049-14-0)
- ethyl 5-amino-1-(2-fluorophenyl)-1H-imidazole-4-carboxylate (CAS 1283340-97-5)
- Ethyl 5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylate (CAS 138907-68-3)
- ethyl 5-amino-1-(3-fluorophenyl)pyrazole-4-carboxylate (CAS 138907-70-7)
- Methyl 5-amino-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-4-carboxylate (CAS 1416344-05-2)
- Methyl 5-amino-1-(3-fluoro-4-methylphenyl)-1H-pyrazole-4-carboxylate (CAS 1416344-39-2)
- Ethyl 1-(4-amino-2-fluorophenyl)-1H-pyrazole-3-carboxylate (CAS 1946828-16-5)
Recommended Standards
- Ethyl 3-fluoro-8-hydroxy-2-methylquinoline-6-carboxylate (CAS 2721375-24-0)
- ethyl 5-amino-1-(2-fluorophenyl)pyrazole-4-carboxylate (CAS 618070-65-8)
- Ethyl 3-(4-Fluorophenyl)-5-methylisoxazole-4-carboxylate (CAS 954230-39-8)
- Ethyl 8-fluoro-4-hydroxy-5-methylquinoline-3-carboxylate (CAS 329698-70-6)
- 151587-54-1 MET004 Methanimidamide, N'-(1,4-dihydro-6-methyl-5-nitro-4-oxo-2-pyrimidinyl)-N,N-dimethyl- (CAS 151587-54-1)
- 3-(1-Ethyl-1h-pyrazol-5-yl)propanal (CAS 1340191-27-6)
- 1-Ethyl-2-[(methylamino)methyl]pyrrolidine-d3 Hydrochloride (CAS 1794827-45-4)
- 3'-Amino-2-fluoro-[1,1'-biphenyl]-4-carboxylic acid (CAS 1261928-51-1)
- 2,6-Dichloro-alpha-(trifluoromethyl)benzyl Alcohol (CAS 1146854-22-9)
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- tetrasodium2-methyl-1,4-naphthylenebis(phosphate) (CAS 131-13-5)
- 5-Chloro-2-fluoro-3-methylpyridine (CAS 375368-84-6)
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