Palbociclib Impurity 196 CAS 3066072-08-7
| CAS No. | 3066072-08-7 |
| Molecular Formula | C27H36N8O3 |
| Molecular Weight | 520.63 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Palbociclib Impurity 196 (CAS 3066072-08-7, C27H36N8O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C27H36N8O3, Palbociclib Impurity 196 contains a steroid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 520.63 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H36N8O3 |
| Molecular Weight | 520.63 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2005 |
| Nitrogen Atoms | 8 |
Related Palbociclib Standards
- Palbociclib Impurity 139 (CAS CATO-C4X-1125139)
- Palbociclib Sulfamic Acid (CAS CATO-C4X-112536)
- Palbociclib Impurity 16 (CAS CATO-C4X-112516)
- Palbociclib Impurity 76 (CAS 1941177-45-2)
- Palbociclib Impurity 195 (CAS 3060653-14-4)
- Palbociclib Impurity 18 (CAS 571189-65-6)
- Palbociclib impurity 129 (CAS CATO-C4X-1125129)
- Palbociclib Impurity 198 (CAS CATO-C4X-1125198)
Recommended Standards
- Tos-PEG5-C2-Boc (CAS 850090-10-7)
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- THP-PEG8-Tos (CAS 669556-37-0)
- Dicyclohexyl(4-methoxy-3-(2,4,6-trimethoxyphenyl)naphthalen-2-yl)phosphine (CAS 1332745-81-9)
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- Famciclovir impurity 3 (CAS 172529-94-1)
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