Palbociclib Impurity 18 CAS 571189-65-6
| CAS No. | 571189-65-6 |
| Molecular Formula | C27H35N7O3 |
| Molecular Weight | 505.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Palbociclib Impurity 18 (CAS 571189-65-6) is a certified pharmaceutical impurity reference standard with the molecular formula C27H35N7O3 and a molecular weight of 505.61 g/mol.
Palbociclib Impurity 18 (C27H35N7O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Palbociclib Impurity 18 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C27H35N7O3 |
| Molecular Weight | 505.61 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Nitrogen Atoms | 7 |
Related Palbociclib Standards
- Palbociclib impurity 129 (CAS CATO-C4X-1125129)
- Palbociclib Impurity 198 (CAS CATO-C4X-1125198)
- Palbociclib Impurity 103 (CAS 2270982-31-3)
- Palbociclib Impurity 79 (CAS CATO-C4X-112579)
- Palbociclib Impurity 85 (CAS CATO-C4X-112585)
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- Palbociclib Impurity 139 (CAS CATO-C4X-1125139)
- Palbociclib Impurity 167 (CAS CATO-C4X-1125167)
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- 1-Phenethyl-3-phenylurea (CAS 18006-56-9)
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- Evobrutinib (CAS 1415823-73-2)
- 1-(2-Bromophenyl)ethanol (CAS 5411-56-3)
- (E)-1-(piperazin-1-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one (CAS 88053-13-8)
- 3-((Diethylamino)methyl)benzaldehyde (CAS 911431-50-0)
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