Ethyl 6-(4-chloro-2-methylphenoxy)-5-cyano-2-phenylnicotinate CAS 306980-21-2
| CAS No. | 306980-21-2 |
| Molecular Formula | C22H17ClN2O3 |
| Molecular Weight | 392.83 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ethyl 6-(4-chloro-2-methylphenoxy)-5-cyano-2-phenylnicotinate.
Ethyl 6-(4-chloro-2-methylphenoxy)-5-cyano-2-phenylnicotinate (CAS 306980-21-2), molecular formula C22H17ClN2O3 and molecular weight 392.83 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, Ethyl 6-(4-chloro-2-methylphenoxy)-5-cyano-2-phenylnicotinate (C22H17ClN2O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 15.0, corresponding to approximately 15 ring(s) or double-bond equivalent(s). With a molecular weight of 392.83 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H17ClN2O3 |
| Molecular Weight | 392.83 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Ethyl Standards
- 4,4'-(5-Chloro-4-(4-hydroxybenzyl)-1H-imidazole-1,2-diyl)diphenol (CAS 885268-49-5)
- N-(3-Chloro-4-fluorophenyl)-2-((4-ethyl-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 573707-56-9)
- 3-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanyl}-5-[(2Z)-2-(methoxyimino)ethyl]-1,2-thiazole-4-carbonitrile (CAS 338413-08-4)
- 5-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-2-(p-tolyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine (CAS 250714-13-7)
- N'-(2-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)acetyl)-N,N-dimethylformohydrazonamide (CAS 338979-30-9)
- N-(4-chloro-3-nitrophenyl)-2-(4-(4-fluorophenyl)piperazin-1-yl)acetamide (CAS 329779-14-8)
- Benzyl 4-(((4-chloro-2-fluorophenyl)amino)methyl)-4-hydroxypiperidine-1-carboxylate (CAS 1330583-65-7)
- 1-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}-2-(morpholin-4-yl)ethan-1-one (CAS 338979-16-1)
Recommended Standards
- N-[(4-Chlorophenyl)methyl]-2,7-dimethyl-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxamide (CAS 338751-40-9)
- 1-Benzyl-2-oxo-2,3-dihydro-1H-indol-3-yl N-(3-chlorophenyl)carbamate (CAS 400076-65-5)
- (S)-3-(4-(2-Amino-6-chloropyrimidin-4-yl)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid (CAS 1033804-86-2)
- 1,4-Diamino-7-chloro-2-phenethoxyanthracene-9,10-dione (CAS 88605-49-6)
- 1-(5-Chloro-2-methoxyphenyl)-1h-pyrazole-4-sulfonyl chloride (CAS 1334148-26-3)
- Levonorgestrel acetate-3-ethyldienol Ether (CAS 55547-52-9)
- Tert-butyl 9-fluoro-2,7-diazaspiro[4.5]Decane-7-carboxylate (CAS 1263179-44-7)
- Xylazine EP Impurity C (CAS 19241-16-8)
- 3,5-Bis(heptafluoroisopropyl)-1-phenylpyrazole (CAS 244187-02-8)
- 4-Hydroxypyrimidine (CAS 51953-18-5)
- Upadacitinib Impurity 181 (CAS CATO-C4X-2405181)
- 3,5-Difluoro-4'-methyl-1,1'-biphenyl (CAS 97067-20-4)
- 2-(2-ethoxyphenyl)piperidine (CAS 383128-66-3)
- Peptide Impurity 41 (CAS CATO-CPTD788841)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com