Trimethoprim EP Impurity A CAS 213745-86-9
| CAS No. | 213745-86-9 |
| Molecular Formula | C15H20N4O3 |
| Molecular Weight | 304.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Trimethoprim EP Impurity A (CAS 213745-86-9, C15H20N4O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Trimethoprim EP Impurity A (C15H20N4O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Trimethoprim EP Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H20N4O3 |
| Molecular Weight | 304.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2018 |
| Nitrogen Atoms | 4 |
Related Trimethoprim Standards
- Trimethoprim Impurity 12 (CAS 92653-78-6)
- Trimethoprim EP Impurity G (CAS 78025-68-0)
- Trimethoprim EP Impurity B (CAS 30806-86-1)
- Trimethoprim N-Oxide 1 (CAS 27653-68-5)
- Trimethoprim N-Oxide 3 (CAS 27653-67-4)
- Trimethoprim EP Impurity C (CAS 29606-06-2)
- Trimethoprim-d9 (CAS 1189460-62-5)
- Trimethoprim-d3 (CAS 1189923-38-3)
Recommended Standards
- Ilaprazole Impurity 14 (CAS CATO-C4X-113014)
- Apixaban Impurity 165 (CAS CATO-C4X-1088165)
- 8-(1-ethoxy-2-hydroxy-3-methyl-3-buten-1-yl)-7-methoxy-2h-chromen -2-one 88478-44-8 (CAS 88478-44-8)
- Guaifenesin EP Impurity D (CAS 16929-60-5)
- Ala-Gly-Cys-Lys-Ala(CN)-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH(disulfide bond) (CAS CATO-CPTD788765)
- Erlotinib Impurity 101 (CAS CATO-C4X-1069101)
- Oseltamivir Impurity 35 (CAS CATO-C4X-172035)
- (S)-2-(2,3-dimethoxyphenyl)-2-(methylamino)ethan-1-ol (CAS 1213566-92-7)
- 3-methyl-1H-indol-6-amine (CAS 83696-97-3)
- N-Acetyltyrosine EP Impurity B (CAS 17355-23-6)
- N-(3,4-Dimethylphenyl)-2-(1H-pyrrol-1-yl)propanamide (CAS 887029-20-1)
- Tumericoleoresin (CAS 8024-37-1)
- Ethyl 5-iodo-6-oxo-1,6-dihydropyridine-3-carboxylate (CAS 160729-80-6)
- Acetyl tetrapeptide-9(Dermican LS 9837) (CAS 928006-50-2)
Why CATO?
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