Trimethoprim EP Impurity C CAS 29606-06-2
| CAS No. | 29606-06-2 |
| Molecular Formula | C14H18N4O4 |
| Molecular Weight | 306.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Trimethoprim EP Impurity C (CAS 29606-06-2), a pharmacopoeial impurity reference standard (molecular formula C14H18N4O4, MW 306.32 g/mol) used for the identification and quantification of trace impurities in APIs.
Trimethoprim EP Impurity C (C14H18N4O4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H18N4O4 |
| Molecular Weight | 306.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1965 |
| Nitrogen Atoms | 4 |
Related Trimethoprim Standards
- Trimethoprim N-Oxide 1 (CAS 27653-68-5)
- Trimethoprim N-Oxide 3 (CAS 27653-67-4)
- Trimethoprim EP Impurity A (CAS 213745-86-9)
- Trimethoprim Impurity 12 (CAS 92653-78-6)
- Trimethoprim EP Impurity G (CAS 78025-68-0)
- Trimethoprim EP Impurity B (CAS 30806-86-1)
- Trimethoprim-d9 (CAS 1189460-62-5)
- Trimethoprim-d3 (CAS 1189923-38-3)
Recommended Standards
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- Ciprofloxacin Hydrochloride EP Impurity D (CAS 526204-10-4)
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- 5-Bromo-1-cyclopropylpyridin-2(1H)-one (CAS 1193334-67-6)
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- 2-Iodo-5-(pyrrolidin-1-yl)pyridine (CAS 1704065-01-9)
- 7-Bromo-2,3-dimethoxy-5-methylquinoxaline (CAS 187479-69-2)
- 4,6-Dichloro-1-(methylamino)-2,3-dihydro-1h-inden-2-ol hydrochloride (CAS 1172327-40-0)
- 5-Amino-4-cyano-3-(cyanomethyl)pyrazole (CAS 54711-21-6)
- D-[Phe]6-Liraglutide (CAS CATO-C4X-199235)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com