Furosemide EP Impurity C CAS 3086-91-7
| CAS No. | 3086-91-7 |
| Molecular Formula | C7H7ClN2O4S |
| Molecular Weight | 250.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Furosemide EP Impurity C.
CATO supplies Furosemide EP Impurity C (CAS 3086-91-7), a pharmacopoeial impurity reference standard (molecular formula C7H7ClN2O4S, MW 250.66 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Furosemide EP Impurity C (C7H7ClN2O4S) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H7ClN2O4S |
| Molecular Weight | 250.66 g/mol |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Furosemide Standards
- Furosemide Impurity 50 (CAS 64174-54-5)
- Furosemide Impurity 11 (CAS CATO-C4X-140211)
- Furosemide Impurity 12 (CAS 74793-12-7)
- Furosemide Impurity 59 (CAS 518336-22-6)
- Furosemide Impurity 64 (CAS 116436-17-0)
- Furosemide Impurity 51 (CAS CATO-C4X-140251)
- Furosemide Impurity 21 (CAS 30170-04-8)
- Furosemide Impurity 34 (CAS 6660-65-7)
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Why CATO?
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com