(2-Chloro-4-(difluoromethoxy)phenyl)boronic acid CAS 313545-33-4
| CAS No. | 313545-33-4 |
| Molecular Formula | C7H6BClF2O3 |
| Molecular Weight | 222.38 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
(2-Chloro-4-(difluoromethoxy)phenyl)boronic acid (C7H6BClF2O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
(2-Chloro-4-(difluoromethoxy)phenyl)boronic acid (CAS 313545-33-4) is a high-purity analytical reference standard with the molecular formula C7H6BClF2O3 and a molecular weight of 222.38 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (2-Chloro-4-(difluoromethoxy)phenyl)boronic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H6BClF2O3 |
| Molecular Weight | 222.38 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- (3-Chloro-2,6-difluoro-4-methoxyphenyl)boronic acid (CAS 1298047-44-5)
- 4-Chloro-3-(difluoromethoxy)phenylboronic acid (CAS 1310949-72-4)
- [3-Chloro-5-(difluoromethoxy)phenyl]boronic acid (CAS 2377611-72-6)
- 4-Chloro-2,3-difluoro-5-methoxyphenylboronic acid (CAS 2121513-09-3)
- 2-(((3-Chloro-4-methylphenyl)amino)methyl)isoindoline-1,3-dione (CAS 84501-73-5)
- (2-Chloro-4-(1H-imidazol-1-yl)phenyl)boronic acid (CAS 2225180-94-7)
- (2-Chloro-4-(1H-pyrazol-1-yl)phenyl)boronic acid (CAS 2225180-95-8)
- (3-Chloro-4-(1H-imidazol-1-yl)phenyl)boronic acid (CAS 2225177-00-2)
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