(2-Chloro-6-fluorophenyl)boronic acid CAS 313545-32-3
| CAS No. | 313545-32-3 |
| Molecular Formula | C6H5BClFO2 |
| Molecular Weight | 174.37 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 174.37 g/mol gives (2-Chloro-6-fluorophenyl)boronic acid distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
(2-Chloro-6-fluorophenyl)boronic acid (CAS 313545-32-3), molecular formula C6H5BClFO2 and molecular weight 174.37 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (2-Chloro-6-fluorophenyl)boronic acid (C6H5BClFO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures (2-Chloro-6-fluorophenyl)boronic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C6H5BClFO2 |
| Molecular Weight | 174.37 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 3-Chloro-4-fluorophenylboronic Acid (CAS 144432-85-9)
- 4-Chloro-2-fluorophenylboronic Acid (CAS 160591-91-3)
- 2-Chloro-3-fluorophenylboronic Acid (CAS 871329-52-1)
- 2-Chloro-5-fluorophenylboronic Acid (CAS 444666-39-1)
- 3-Chloro-2-fluorophenylboronic Acid (CAS 352535-82-1)
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