Paroxetine Impurity 44 CAS 317323-77-6
| CAS No. | 317323-77-6 |
| Molecular Formula | C20H24FNO3S |
| Molecular Weight | 377.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Paroxetine Impurity 44 (CAS 317323-77-6) is a certified pharmaceutical impurity reference standard with the molecular formula C20H24FNO3S and a molecular weight of 377.47 g/mol.
Based on its molecular formula C20H24FNO3S, Paroxetine Impurity 44 contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 377.47 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H24FNO3S |
| Molecular Weight | 377.47 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Paroxetine Standards
- Paroxetine Impurity 61 (CAS CATO-C4X-103561)
- Paroxetine Impurity 40 (CAS CATO-C4X-103540)
- Paroxetine Impurity 64 (CAS 2361294-43-9)
- Paroxetine Hydrochloride Hemihydrate - Impurity C (Freebase) (CAS 1395408-54-4)
- Paroxetine Impurity 69 (CAS CATO-C4X-103569)
- Paroxetine Impurity 47 (CAS 105813-40-9)
- Paroxetine HCl Anhydrous EP Impurity J (CAS CATO-C4X-103534)
- Paroxetine Impurity 27 (CAS 2575750-19-3)
Recommended Standards
- 3-Piperidinemethanol,4-(4-fluorophenyl)-1-(phenylmethyl)-,3-methanesulfonate,(3S,4R) (CAS 201855-71-2)
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- Loxoprofen Impurity 8 (CAS CATO-C4X-14888)
- 1-(Tert-butyl) 4-ethyl 4-(4-methoxybenzyl)piperidine-1,4-dicarboxylate (CAS 932710-58-2)
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- Cefpirome Impurity 14 (CAS CATO-C4X-120714)
- 5-(2,6-difluorophenyl)-5-methylimidazolidine-2,4-dione (CAS 1052550-71-6)
- 1,2:3,4-Di-O-isopropylidene-6-thio-a-D-galactopyranose, 97% (CAS 16714-07-1)
- n-[(4-aminophenyl)methyl]-N-(propan-2-yl)acetamide (CAS 1156857-35-0)
- 2-{2-[3-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}acetic acid (CAS 886361-94-0)
- BI-6C9 (CAS 791835-21-7)
- N-Methyl-2-(pyrimidin-5-yloxy)ethanamine (CAS 310881-00-6)
- Tirzepatide Impurity 21 X TFA Salt (CAS CATO-C4X-324021)
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