Clopidogrel Impurity 91 CAS 317322-48-8
| CAS No. | 317322-48-8 |
| Molecular Formula | C16H18ClNO4S |
| Molecular Weight | 355.84 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Clopidogrel Impurity 91.
CATO supplies Clopidogrel Impurity 91 (CAS 317322-48-8), a pharmacopoeial impurity reference standard (molecular formula C16H18ClNO4S, MW 355.84 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Clopidogrel Impurity 91 (C16H18ClNO4S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 355.84 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Clopidogrel Impurity 91 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H18ClNO4S |
| Molecular Weight | 355.84 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Clopidogrel Standards
- Clopidogrel thiol metabolite H3 (CAS 1352123-33-1)
- Clopidogrel thiol metabolite H2 (CAS 1415550-27-4)
- Clopidogrel thiol metabolite H1 (CAS 1415550-28-5)
- Clopidogrel Metabolite I (Mixture of Diastereomers) (CAS 767612-34-0)
- Clopidogrel Impurity 100 (CAS CATO-C4X-1029100)
- Clopidogrel Impurity 50 (CAS CATO-C4X-102950)
- Clopidogrel Impurity 124 (CAS 1346231-35-3)
- Clopidogrel Impurity 72 (CAS CATO-C4X-102972)
Recommended Standards
- Ceritinib Impurity 58 (CAS CATO-C4X-104858)
- Tiaramide (CAS 32527-55-2)
- (2E)-N-(4-Chlorophenyl)-3-(4-phenylpiperazin-1-yl)but-2-enamide (CAS 1025162-94-0)
- Ethyl 4-chloro-5-methyl-2-(morpholin-4-ylmethyl)thieno[2,3-d]pyrimidine-6-carboxylate (CAS 735305-32-5)
- Bumetanide Impurity 94 (CAS 202209-14-1)
- Levofloxacin impurity 66 (CAS CATO-C4X-137166)
- Venetoclax Impurity 36 (CAS CATO-C4X-249536)
- Naproxen EP Impurity G (R-Naproxen) (CAS 23979-41-1)
- 1-Benzyloxy-2-chloro-4-fluorobenzene (CAS 918524-11-5)
- 2-Chloro-5-ethynylpyridine (CAS 263012-63-1)
- 1-Cyclopropyl-6-fluoro-1,2,3-benzotriazole (CAS 1365271-45-9)
- 3-((2-Chloro-1H-indol-3-yl)methylene)indolin-2-one (CAS 220749-41-7)
- (R)-4-benzyl-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid (CAS 1245643-13-3)
- Prolactin-Releasing Peptide (12-31) (human) (CAS 235433-36-0)
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