Domperidone Impurity 25 CAS 3209-22-1
| CAS No. | 3209-22-1 |
| Molecular Formula | C6H3Cl2NO2 |
| Molecular Weight | 192.00 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Domperidone Impurity 25 (C6H3Cl2NO2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies Domperidone Impurity 25 (CAS 3209-22-1), a pharmacopoeial impurity reference standard (molecular formula C6H3Cl2NO2, MW 192.00 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H3Cl2NO2 |
| Molecular Weight | 192.00 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Domperidone Standards
- Domperidone Impurity 24 (CAS 99-54-7)
- Domperidone Impurity 19 (CAS 53786-42-8)
- Domperidone Impurity 39 (CAS 34840-27-2)
- Domperidone Impurity 17 (CAS 72798-66-4)
- Domperidone Impurity 22 (CAS 52099-72-6)
- Domperidone Impurity 31 (CAS 95926-75-3)
- Domperidone Impurity 23 (CAS 62780-89-6)
- Domperidone Impurity N8 (CAS 58859-46-4)
Recommended Standards
- Favipiravir Impurity 16 (CAS 1023813-21-9)
- 4,6-Dichloropicolinic acid (CAS 88912-25-8)
- Avatrombopag Impurity 32 (CAS 41667-95-2)
- N-(4,6-Dichloropyrimidin-2-yl)formamide (CAS 58910-74-0)
- Entecavir Impurity 55 (CAS 1354695-84-3)
- Mivacurium chloride Impurity 43 (CAS CATO-C4X-137543)
- Isavuconazole Impurity 109 (CAS CATO-C4X-1236109)
- (3AR,6aS)-5-methyloctahydrocyclopenta[c]pyrrol-5-ol (CAS 2567756-10-7)
- Mupirocin Impurity 22 (CAS CATO-C4X-170622)
- n-[2-(dimethylamino)ethyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide dihydrochloride (CAS 1214014-55-7)
- Tert-butyl (2s,4s)-4-hydroxypyrrolidine-2-carboxylate (CAS 659747-06-5)
- Dinotefuran-13C5 (CAS CATO-CCPD102485)
- 2-(5-Aminopyridin-2-yl)acetic acid (CAS 415912-76-4)
- Acetyl Tripeptide-1 (CAS 350595-76-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com