Domperidone Impurity 17 CAS 72798-66-4
| CAS No. | 72798-66-4 |
| Molecular Formula | C10H10N2O |
| Molecular Weight | 174.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Domperidone Impurity 17 (CAS 72798-66-4, C10H10N2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Domperidone Impurity 17 (C10H10N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C10H10N2O |
| Molecular Weight | 174.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1977 |
| Nitrogen Atoms | 2 |
Related Domperidone Standards
- Domperidone Impurity 22 (CAS 52099-72-6)
- Domperidone Impurity 31 (CAS 95926-75-3)
- Domperidone Impurity N8 (CAS 58859-46-4)
- Domperidone Impurity 39 (CAS 34840-27-2)
- Domperidone Impurity 19 (CAS 53786-42-8)
- Domperidone Impurity 24 (CAS 99-54-7)
- Domperidone Impurity 25 (CAS 3209-22-1)
- Domperidone Impurity 23 (CAS 62780-89-6)
Recommended Standards
- Raltitrexed Impurity 45 (CAS CATO-C4X-138645)
- Raltitrexed Impurity 2 (CAS 18731-19-6)
- Pregabalin Impurity 119 (CAS CATO-C4X-1312119)
- Naproxen EP Impurity H (CAS 5111-66-0)
- Ketoprofen Impurity 78 (CAS 136656-97-8)
- Milrinone impurity 41 (CAS CATO-C4X-109141)
- Pramipexole Impurity 65 (CAS CATO-C4X-110765)
- 4-Methoxy-1H-indol-7-amine (CAS 292636-16-9)
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- 2H-Naphtho[1,8-cd]isoxazole (CAS 42214-70-0)
- 1-((Allyloxy)methyl)-2-bromobenzene (CAS 87280-01-1)
- 3-Formyl-4-hydroxy-5-iodobenzoic acid (CAS 33257-38-4)
- 2-(2,6-Dichloro-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2121514-25-6)
- Palmitoyl Tripeptide-5 TFA (CAS 623172-55-4（free base）)
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