1-{4-[(1Z)-1-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]hydrazin-1-ylidene}ethyl]phenyl}-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile CAS 321432-43-3
| CAS No. | 321432-43-3 |
| Molecular Formula | C19H12ClF3N6O2 |
| Molecular Weight | 448.79 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1-{4-[(1Z)-1-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]hydrazin-1-ylidene}ethyl]phenyl}-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 1-{4-[(1Z)-1-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]hydrazin-1-ylidene}ethyl]phenyl}-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile (CAS 321432-43-3), a certified reference material (molecular formula C19H12ClF3N6O2, MW 448.79 g/mol) for analytical method development and quality control.
The molecular framework of 1-{4-[(1Z)-1-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]hydrazin-1-ylidene}ethyl]phenyl}-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile (C19H12ClF3N6O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 1-{4-[(1Z)-1-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]hydrazin-1-ylidene}ethyl]phenyl}-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H12ClF3N6O2 |
| Molecular Weight | 448.79 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 6 |
Related Z Standards
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Recommended Standards
- (E)-[(4-chlorophenyl)methoxy][4-(6-chloropyridin-3-yl)-3-[(6-chloropyridin-3-yl)methyl]butan-2-ylidene]amine 5W-0864 866040-63-3 (CAS 866040-63-3)
- Chlorobis(dimethylglyoximato)[4-(dimethylamino)pyridine]cobalt(III) (CAS 483979-48-2)
- (9Z,12Z)-Dodecyl octadeca-9,12-dienoate (CAS 42935-00-2)
- N-[3,5-Bis(trifluoromethyl)phenyl]-3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carboxamide (CAS 1020252-04-3)
- N-tert-Butyl-d9-phenyl-d5-nitrone (spin trap) (CAS 119391-92-3)
- IDE 2 (CAS 1136466-93-7)
- 2-(4-(3-Chlorophenyl)piperazin-1-yl)-1-phenylethan-1-ol (CAS 95125-91-0)
- 2-chloro-N-[4-(difluoromethoxy)benzyl]-N-methylacetamide (CAS 851903-50-9)
- Apalutamide impurity 88 (CAS 1367708-38-0)
- (1R,2S)-2-(2-Tosyl-1,2-dihydroxyethyl)-6-fluorochromane (CAS 303176-40-1)
- (3-Bromophenyl)(2,3-dimethylphenyl)methanol (CAS 1285480-74-1)
- Ganirelix lmpurity 16 (CAS CATO-C4X-237316)
- 8-Aza-N6-benzoyl-7-deaza-2-deoxy-5-O-DMT-adenosine (CAS 119803-27-9)
- Semaglutide-d15 (CAS 910463-68-2(non-labelled))
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