Zidovudine Impurity N6 CAS 32189-36-9
| CAS No. | 32189-36-9 |
| Molecular Formula | C8H7ClO3 |
| Molecular Weight | 186.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Zidovudine Impurity N6 is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Zidovudine Impurity N6 (CAS 32189-36-9) is a certified pharmaceutical impurity reference standard with the molecular formula C8H7ClO3 and a molecular weight of 186.59 g/mol.
Based on its molecular formula C8H7ClO3, Zidovudine Impurity N6 contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 186.59 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H7ClO3 |
| Molecular Weight | 186.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
| Halogen Content | Cl-containing |
Related Zidovudine Standards
- Zidovudine impurity B (CAS 61008-98-8)
- Zidovudine Impurity F (CAS 16053-52-4)
- Zidovudine Impurity 19 (CAS CATO-C4X-178319)
- Zidovudine EP Impurity C (CAS 65-71-4)
- Zidovudine EP Impurity D (CAS 76-84-6)
- Zidovudine EP Impurity B (CAS 25526-94-7)
- Zidovudine Impurity 04 (CAS 73971-82-1)
- Zidovudine Impurity 13 (CAS 123606-70-2)
Recommended Standards
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- (4-Chloro-3-nitrophenyl)methanamine (CAS 100398-63-8)
- Daprodustat Impurity 18 (CAS 117043-46-6)
- Levamisole EP Impurity C (CAS 32190-33-3)
- Ethosuximide impurity 9 (CAS CATO-C4X-26259)
- 6-amino-5-methyl-3-Pyridinecarbonitrile (CAS 183428-91-3)
- 6-(Aminomethyl)-3-(difluoromethyl)-2-fluoropyridin-4-amine (CAS 1805117-04-7)
- Boc-Glycinamide (CAS 35150-09-5)
- 2-((2-Benzoylphenyl)amino)propanoic acid (CAS 76477-50-4)
- 2-(Dimethylamino)-2-(2-methoxyphenyl)acetic acid (CAS 1101767-98-9)
- 5-Fluoro-7-methyl-1H-indole (CAS 1082041-52-8)
- Semaglutide impurity 27 (CAS CATO-C4X-222627)
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