Tofacitinib Impurity N76 CAS 322728-22-3
| CAS No. | 322728-22-3 |
| Molecular Formula | C6H5N3O |
| Molecular Weight | 135.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Tofacitinib Impurity N76 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
As a process- or degradation-related impurity, Tofacitinib Impurity N76 (CAS 322728-22-3, C6H5N3O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C6H5N3O, Tofacitinib Impurity N76 contains an amide group, a hydroxyl group, an ether linkage, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 135.12 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C6H5N3O |
| Molecular Weight | 135.12 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 3 |
Related Tofacitinib Standards
- Tofacitinib Impurity 91 (CAS 3680-71-5)
- Tofacitinib Impurity 63 (CAS 1354469-76-3)
- Tofacitinib Impurity 117 (CAS 873-83-6)
- Tofacitinib Impurity 186 (CAS 89600-66-8)
- Tofacitinib Impurity 116 (CAS 77862-24-9)
- Tofacitinib Impurity 180 (CAS 100047-45-8)
- Tofacitinib Impurity N47 (CAS 52090-68-3)
- Tofacitinib Impurity 104 (CAS 39929-79-8)
Recommended Standards
- 22911-39-3 U1Q234E2R1 1,4-Butanediol mononitrate UNII-U1Q234E2R1 1,4-Butanediol, 1-nitrate 1,4-Butanediol, mononitrate 1,4-Butylene glycol mononitrate 1-Hydroxy-4-butyl nitrate (CAS 22911-39-3)
- 55662-68-5 5H,8H-Imidazo[1,2-a]pyrimidin-5-one MFCD19216604 (CAS 55662-68-5)
- Pyridine-3,5-dicarbaldehyde (CAS 6221-04-1)
- 74421-65-1 Butanamide,2,3,4-trihydroxy-, (2R,3S)- CTK5D9851 (CAS 74421-65-1)
- Gefitinib Impurity 36 HCl (CAS CATO-C4X-111736)
- Sildenafil Impurity N4 (CAS 374776-34-8 (free base))
- Hydroxychloroquine Impurity 20 (CAS 630067-21-9)
- N-{2-[(4-bromo-2-methylphenyl)amino]-2-oxoethyl}-2-chloro-N-methylacetamide (CAS 1050909-49-3)
- Cis-3-Hexen-1-Ol (CAS 928-96-1)
- 3-(methoxymethyl)-1H-1,2,4-triaZol-5-ylamine (CAS 105445-19-0)
- 2-((2-Allyl-2-methylcyclohex-3-en-1-yl)oxy)ethanol (CAS 89654-09-1)
- N,N'-((azanediylbis(methylene))bis(3,1-phenylene))diacetamide (CAS 866155-44-4)
- 3-(4-Methoxyphenyl)furan (CAS 20842-11-9)
- endo-Ser39-Tirzepatide (CAS CATO-CPTD788935)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com