Tofacitinib Impurity 117 CAS 873-83-6
| CAS No. | 873-83-6 |
| Molecular Formula | C4H5N3O2 |
| Molecular Weight | 127.10 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Tofacitinib Impurity 117 (CAS 873-83-6) is a certified pharmaceutical impurity reference standard with the molecular formula C4H5N3O2 and a molecular weight of 127.10 g/mol.
The molecular framework of Tofacitinib Impurity 117 (C4H5N3O2) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C4H5N3O2 |
| Molecular Weight | 127.10 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 3 |
Related Tofacitinib Standards
- Tofacitinib Impurity 186 (CAS 89600-66-8)
- Tofacitinib Impurity 63 (CAS 1354469-76-3)
- Tofacitinib Impurity 116 (CAS 77862-24-9)
- Tofacitinib Impurity N76 (CAS 322728-22-3)
- Tofacitinib Impurity 91 (CAS 3680-71-5)
- Tofacitinib Impurity 54 (CAS 6066-82-6)
- Tofacitinib Impurity 106 (CAS 3430-27-1)
- Tofacitinib Impurity 180 (CAS 100047-45-8)
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