Tadalafil Impurity 73 CAS 326-61-4
| CAS No. | 326-61-4 |
| Molecular Formula | C10H10O4 |
| Molecular Weight | 194.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Tadalafil Impurity 73 (CAS 326-61-4) is a certified pharmaceutical impurity reference standard with the molecular formula C10H10O4 and a molecular weight of 194.18 g/mol.
Tadalafil Impurity 73 (C10H10O4) contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Tadalafil Impurity 73 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H10O4 |
| Molecular Weight | 194.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Tadalafil Standards
- Tadalafil Impurity 132 (CAS CATO-C4X-1087132)
- Tadalafil Impurity 131 (CAS 209120-51-4)
- Tadalafil Impurity 118 (CAS CATO-C4X-1087118)
- Tadalafil Impurity 116 (CAS 154030-29-2)
- Tadalafil Impurity 99 (CAS 114152-23-7)
- Tadalafil Impurity 135 (CAS CATO-C4X-1087135)
- Tadalafil Impurity 18 (CAS 153-94-6)
- Tadalafil Impurity 163 (CAS CATO-C4X-1087163)
Recommended Standards
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- Alanyl Glutamine Impurity 7 (CAS CATO-C4X-19747)
- 2-(3-Isobutoxyphenyl)-6-methylquinoline-4-carboxylic acid (CAS 438221-81-9)
- 2-Oxo-1-phenyl-1,2-dihydropyridine-3-carbonitrile (CAS 1198411-44-7)
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- Semaglutide impurity 272 (CAS CATO-C4X-2226272)
- N-(4-bromo-5-methyl-1H-pyrazol-3-yl)acetimidamide (CAS 1304777-34-1)
- 4-Amino-5-heptyl-4H-1,2,4-triazole-3-thiol (CAS 56240-89-2)
- Semaglutide impurity 201 (CAS CATO-C4X-2226201)
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