Crisaborole Impurity 22 CAS CATO-C4X-202122
| CAS No. | CATO-C4X-202122 |
| Molecular Formula | C14H7Br2NO2 |
| Molecular Weight | 381.02 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Crisaborole Impurity 22 (C14H7Br2NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 381.02 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO supplies Crisaborole Impurity 22 (CAS CATO-C4X-202122), a pharmacopoeial impurity reference standard (molecular formula C14H7Br2NO2, MW 381.02 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Crisaborole Impurity 22 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H7Br2NO2 |
| Molecular Weight | 381.02 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Crisaborole Standards
- Crisaborole impurity 160 (CAS CATO-C4X-2021160)
- Crisaborole Impurity 144 (CAS CATO-C4X-2021144)
- Crisaborole impurity 109 (CAS CATO-C4X-2021109)
- Crisaborole impurity 119 (CAS CATO-C4X-2021119)
- Crisaborole Impurity 103 (CAS CATO-C4X-2021103)
- Crisaborole Impurity 56 (CAS CATO-C4X-202156)
- Crisaborole lmpurity 68 (CAS 943311-78-2)
- Crisaborole Impurity 147 (CAS CATO-C4X-202147)
Recommended Standards
- Bis(4-chlorophenyl)diselenide (CAS 20541-49-5)
- 1-Amino-2,4-dibromo-anthraquinone (CAS 81-49-2)
- 2-Amino-1,3-dibromoanthracene-9,10-dione (CAS 6288-68-2)
- N-(4-bromo-2-nitro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroacetamide (CAS 156425-51-3)
- Roxadustat Impurity 65 (CAS CATO-C4X-221365)
- Binimetinib Impurity 4 (CAS CATO-C4X-30504)
- Regorafenib Impurity 37 (CAS CATO-C4X-104737)
- Sinalbin (CAS 20196-67-2)
- Pyrrolo[1,2-b]pyridazine-7-carboxylic Acid (CAS 1378467-76-5)
- Cresidinesulfonamide (CAS 98489-97-5)
- Methyl 2-{[(3-methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-yliden)methyl]amino}acetate (CAS 159592-98-0)
- Carbamoyltryptophan (CAS 98299-50-4)
- 4-((2-Fluorophenyl)thio)pentan-2-one (CAS 1342907-25-8)
- Heptapeptide-6 (CAS CATO-CPTD788823)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com