Quetiapine EP Impurity S CAS 329216-63-9
| CAS No. | 329216-63-9 |
| Molecular Formula | C21H25N3O3S |
| Molecular Weight | 399.51 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Quetiapine EP Impurity S.
Quetiapine EP Impurity S (CAS 329216-63-9) is a certified pharmaceutical impurity reference standard with the molecular formula C21H25N3O3S and a molecular weight of 399.51 g/mol.
The molecular framework of Quetiapine EP Impurity S (C21H25N3O3S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H25N3O3S |
| Molecular Weight | 399.51 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Quetiapine Standards
- Quetiapine EP Impurity H (CAS 1076199-40-0)
- Quetiapine Impurity 4 (CAS 1241800-24-7)
- Quetiapine EP Impurity F (CAS 848814-27-7)
- Quetiapine Impurity N2 (CAS 2206135-50-2)
- Quetiapine (CAS 111974-69-7)
- Quetiapine Impurity 35 (CAS 329216-65-1)
- Quetiapine Impurity 51 (CAS 1185170-04-0)
- Quetiapine impurity 73 (CAS CATO-C4X-124473)
Recommended Standards
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- Brinzolamide Impurity 9 (CAS CATO-C4X-19409)
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- (2-Methoxy-3-methylphenyl)methanol (CAS 74090-48-5)
- 7-Chloro-5-fluoroindoline-2,3-dione (CAS 259860-03-2)
- 3,4,5,6-Tetrahydrophthalic anhydride (CAS 2426-02-0)
- Febuxostat impurity 129 (CAS CATO-C4X-1162105)
- (S)-2-Chloro-N-isopropyl-N-((1-methylpyrrolidin-2-yl)methyl)acetamide (CAS 1354015-03-4)
- 2-(2-Bromo-4-fluorobenzyl)propane-1,3-diol (CAS 1533840-18-4)
- Liraglutide Impurity 15 TFA Salt (CAS CATO-C4X-199215)
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