Quetiapine EP Impurity F CAS 848814-27-7
| CAS No. | 848814-27-7 |
| Molecular Formula | C21H27N3O3S |
| Molecular Weight | 401.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Quetiapine EP Impurity F.
As a process- or degradation-related impurity, Quetiapine EP Impurity F (CAS 848814-27-7, C21H27N3O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Quetiapine EP Impurity F (C21H27N3O3S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H27N3O3S |
| Molecular Weight | 401.52 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Quetiapine Standards
- Quetiapine Impurity 4 (CAS 1241800-24-7)
- Quetiapine EP Impurity S (CAS 329216-63-9)
- Quetiapine EP Impurity H (CAS 1076199-40-0)
- Quetiapine Impurity N2 (CAS 2206135-50-2)
- Quetiapine Impurity 35 (CAS 329216-65-1)
- Quetiapine Impurity 51 (CAS 1185170-04-0)
- Quetiapine impurity 73 (CAS CATO-C4X-124473)
- Quetiapine EP Impurity L (CAS 1371638-11-7)
Recommended Standards
- N-[3,5-di(trifluoromethyl)phenyl]-N'-(1,2,2-trichlorovinyl)urea (CAS 646989-41-5)
- N,N-Dimethyl-2-(pyrrolidin-1-yl)-6-tosyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine (CAS 1081391-73-2)
- Ethyl 1-(4-methylbenzyl)-4-(phenylsulfonyl)piperidine-4-carboxylate (CAS 860649-16-7)
- (S)-N-(1-((5-Isobutyl-1,3,4-thiadiazol-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)pyrrolidine-1-carboxamide (CAS 1314015-87-6)
- Dorzagliatin Impurity 20 (CAS CATO-C4X-344120)
- Ponatinib Impurity 44 (Z-Isomer) (CAS CATO-C4X-226944)
- Tazobactam EP Impurity B (CAS 120701-87-3)
- 4-(Difluoromethyl)-2-iodo-5-(trifluoromethoxy)nicotinaldehyde (CAS 1804859-69-5)
- 3-[(4-Isopropyl-3-methylphenoxy)methyl]piperidinehydrochloride (CAS 1219976-40-5)
- Methyl (5-((4-hydroxyphenyl)sulfonyl)-1H-benzo[d]imidazol-2-yl)carbamate (CAS 83101-93-3)
- Ethyl 4,5-dichloro-1h-imidazole-2-carboxylate (CAS 64736-58-9)
- 4-(allyloxy)-2-bromo-5-ethoxybenZoic acid (CAS 486994-79-0)
- methyl 1H-imidazole-5-carboxylate;hydrochloride (CAS 127607-71-0)
- Semaglutide impurity 277 (CAS CATO-C4X-2226277)
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